Results 11 to 20 of about 1,391,897 (268)
The COPD genetic association compendium: a comprehensive online database of COPD genetic associations [PDF]
Human Molecular Genetics, 2009 Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. COPD is thought to arise from the interaction of environmental exposures and genetic susceptibility, and major research efforts are underway to identify genetic determinants of COPD susceptibility.
Castaldi, P. +15 more
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Genetic components in diabetic retinopathy
Indian Journal of Ophthalmology, 2016 Diabetic retinopathy (DR) is a serious complication of diabetes, which is fast reaching epidemic proportions worldwide. While tight glycemic control remains the standard of care for preventing the progression of DR, better insights into DR etiology ...
Bibhudatta Mishra +2 more
doaj +1 more source
PsychArray-Based Genome Wide Association Study of Suicidal Deaths in India
Brain Sciences, 2023 Background: Suicide is a preventable but escalating global health crisis. Genome-wide association studies (GWAS) studies to date have been limited, and some are underpowered.
Chittaranjan Behera +6 more
doaj +1 more source
Progress in Genetic Studies of Tourette’s Syndrome
Brain Sciences, 2017 Tourette’s Syndrome (TS) is a complex disorder characterized by repetitive, sudden, and involuntary movements or vocalizations, called tics. Tics usually appear in childhood, and their severity varies over time.
Yanjie Qi +3 more
doaj +1 more source
Association of Genetic Variation With Keratoconus [PDF]
JAMA Ophthalmology, 2020 Keratoconus is a condition in which the cornea progressively thins and protrudes in a conical shape, severely affecting refraction and vision. It is a major indication for corneal transplant. To discover new genetic loci associated with keratoconus and better understand the causative mechanism of this disease, we performed a genome-wide association ...
Bennet J, McComish +21 more
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Frontiers in Genetics, 2019 Background: Esophageal squamous cell carcinoma (ESCC), one of the most aggressive cancers, is endemic in Sub-Saharan Africa, constituting a major health burden.
Hannah Simba +8 more
doaj +1 more source
Frontiers in Neurology, 2021 Genetic risk factors for Parkinson's disease (PD) risk and progression have been identified from genome-wide association studies (GWAS), as well as studies of familial forms of PD, implicating common variants at more than 90 loci and pathogenic or likely
Katerina Markopoulou +12 more
doaj +1 more source
Annals of Agricultural and Environmental Medicine, 2017 Chronic kidney disease (CKD) is an important challange for healthcare systems wordwide because of its high prevalence and serious late complications.
Joanna Żywiec +3 more
doaj +1 more source
Validation in Genetic Association Studies [PDF]
Briefings in Bioinformatics, 2011 Validation of genetic associations is understood to be a cornerstone for the scientific credibility of the results. To approach this topic, the general concept of genetic association studies is introduced briefly, followed by how the term 'validation' is used in the context of genetic association studies.
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ALDH1A1 Genetic Variations May Modulate Risk of Parkinson’s Disease in Han Chinese Population
Frontiers in Neuroscience, 2021 Background: Studies in animal models have suggested that aldehyde dehydrogenase 1 (encoded by ALDH1A1) protects against Parkinson’s disease (PD) by reducing toxic metabolites of dopamine.
Hui-Hui Fan +11 more
doaj +1 more source