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The Lancet, 2005
We review the rationale behind and discuss methods of design and analysis of genetic association studies. There are similarities between genetic association studies and classic epidemiological studies of environmental risk factors but there are also issues that are specific to studies of genetic risk factors such as the use of particular family-based ...
Cordell HJ, Clayton DG
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We review the rationale behind and discuss methods of design and analysis of genetic association studies. There are similarities between genetic association studies and classic epidemiological studies of environmental risk factors but there are also issues that are specific to studies of genetic risk factors such as the use of particular family-based ...
Cordell HJ, Clayton DG
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Genetic association studies in cardiology
American Heart Journal, 2005The last decade has witnessed the emergence of the genetic association study into the mainstream clinical literature. Technological advances and the Human Genome Project have resulted in widespread interest in exploring these new variables in clinical disease.
Mark P, Donahue, Andrew S, Allen
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The Biomedical & Life Sciences Collection, 2009
Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
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Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
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Genetic association studies: Genes in search of diseases
Neurology, 2002To the Editor: In a recent editorial, Bird et al.1 provide important guidelines to improve the quality of genetic association studies.1 This letter aims to offer additional guidelines for a valid design and analysis of genetic association studies. The authors rightly consider the selection of the controls in a case-control study as an important cause
Slooter, Arjen J C +2 more
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2006
AbstractThis chapter focuses on genetic association studies. The goal of genetic association studies is to investigate the effects of genotypic variation on disease risk. These designs are built on a concept of a genetic cause that closely resembles the concept of a risk factor in epidemiology.
Ezra Susser +3 more
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AbstractThis chapter focuses on genetic association studies. The goal of genetic association studies is to investigate the effects of genotypic variation on disease risk. These designs are built on a concept of a genetic cause that closely resembles the concept of a risk factor in epidemiology.
Ezra Susser +3 more
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2014
In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
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In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
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Genetic Markers: Association Study in Migraine
Cephalalgia, 1995Eleven genetic markers were typed in 112 unrelated patients with migraine (50 with aura, 62 without aura) and compared with a random sample of healthy individuals. No significant differences were found for the ABO and Rh systems, acid phosphatase 1, phosphoglucomutase 1, adenosine deaminase, haptoglobin, transferrin, alpha-1–antitrypsin, and D1S80 ...
J, Pardo +5 more
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Genetic Association Studies in Diabetic Nephropathy
Current Diabetes Reviews, 2012Clinical observations and epidemiological studies have shown that there is familial aggregation of diabetic nephropathy in many ethnic groups, indicating the strong contribution of inherited factors in the development of diabetic nephropathy. Identification of the genes involved in the pathogenesis of diabetic nephropathy may provide better knowledge ...
Harvest F, Gu, Kerstin, Brismar
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