Results 221 to 230 of about 1,290,197 (259)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
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The Lancet, 2005
We review the rationale behind and discuss methods of design and analysis of genetic association studies. There are similarities between genetic association studies and classic epidemiological studies of environmental risk factors but there are also issues that are specific to studies of genetic risk factors such as the use of particular family-based ...
Cordell HJ, Clayton DG
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We review the rationale behind and discuss methods of design and analysis of genetic association studies. There are similarities between genetic association studies and classic epidemiological studies of environmental risk factors but there are also issues that are specific to studies of genetic risk factors such as the use of particular family-based ...
Cordell HJ, Clayton DG
openaire +3 more sources
Genetic association studies in cardiology
American Heart Journal, 2005The last decade has witnessed the emergence of the genetic association study into the mainstream clinical literature. Technological advances and the Human Genome Project have resulted in widespread interest in exploring these new variables in clinical disease.
Mark P, Donahue, Andrew S, Allen
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Genetic association studies: Genes in search of diseases
Neurology, 2002To the Editor: In a recent editorial, Bird et al.1 provide important guidelines to improve the quality of genetic association studies.1 This letter aims to offer additional guidelines for a valid design and analysis of genetic association studies. The authors rightly consider the selection of the controls in a case-control study as an important cause
Slooter, Arjen J C +2 more
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The Biomedical & Life Sciences Collection, 2009
Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
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Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
openaire +2 more sources
2006
AbstractThis chapter focuses on genetic association studies. The goal of genetic association studies is to investigate the effects of genotypic variation on disease risk. These designs are built on a concept of a genetic cause that closely resembles the concept of a risk factor in epidemiology.
Ezra Susser +3 more
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AbstractThis chapter focuses on genetic association studies. The goal of genetic association studies is to investigate the effects of genotypic variation on disease risk. These designs are built on a concept of a genetic cause that closely resembles the concept of a risk factor in epidemiology.
Ezra Susser +3 more
openaire +1 more source
A Bayesian toolkit for genetic association studies
Genetic Epidemiology, 2006AbstractWe present a range of modelling components designed to facilitate Bayesian analysis of genetic‐association‐study data. A key feature of our approach is the ability to combine different submodels together, almost arbitrarily, for dealing with the complexities of real data.
David J, Lunn +2 more
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Genetic Markers: Association Study in Migraine
Cephalalgia, 1995Eleven genetic markers were typed in 112 unrelated patients with migraine (50 with aura, 62 without aura) and compared with a random sample of healthy individuals. No significant differences were found for the ABO and Rh systems, acid phosphatase 1, phosphoglucomutase 1, adenosine deaminase, haptoglobin, transferrin, alpha-1–antitrypsin, and D1S80 ...
J, Pardo +5 more
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Association Studies in Genetics
2011This chapter is devoted at first to a quick review of case control studies in genetic epidemiology. The case–control method is usually applied in genetic epidemiology to elucidate the role of genetic factors and their interaction with environmental factors in the aetiology of human diseases.
Luigi Salmaso +3 more
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