Results 81 to 90 of about 931,040 (332)
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
The Triplet Genetic Code had a Doublet Predecessor
, 2004 Information theoretic analysis of genetic languages indicates that the naturally occurring 20 amino acids and the triplet genetic code arose by duplication of 10 amino acids of class-II and a doublet genetic code having codons NNY and anticodons ...
Patel, Apoorva
core
Molecular Mechanisms and the Significance of Synonymous Mutations
BiomoleculesSynonymous mutations result from the degeneracy of the genetic code. Most amino acids are encoded by two or more codons, and mutations that change a codon to another synonymous codon do not change the amino acid in the gene product.
Peter Oelschlaeger
doaj +1 more source
Efforts and Challenges in Engineering the Genetic Code
Life, 2017 This year marks the 48th anniversary of Francis Crick’s seminal work on the origin of the genetic code, in which he first proposed the “frozen accident” hypothesis to describe evolutionary selection against changes to the genetic code that cause ...
Xiao Lin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
Centrality based analysis of amino acids network [PDF]
Network BiologyA network is a crucial asset in biology for capturing and exploring interaction data in biological systems of many types, such as protein-protein communications, amino acid associations, gene regulation, and cellular metabolism.
Chandra Borah, Tazid Ali
doaj
Logic in the Light of Cognitive Science
Studies in Logic, Grammar and Rhetoric, 2016 Logical theory codifies rules of correct inferences. On the other hand, logical reasoning is typically considered as one of the most fundamental cognitive activities.
Woleński Jan
doaj +1 more source
From Prebiotics to Probiotics: The Evolution and Functions of tRNA Modifications
Life, 2016 All nucleic acids in cells are subject to post-transcriptional chemical modifications. These are catalyzed by a myriad of enzymes with exquisite specificity and that utilize an often-exotic array of chemical substrates.
Katherine M. McKenney, Juan D. Alfonzo
doaj +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source