Results 91 to 100 of about 431,685 (314)
The genetic code as an operational a priori: xenobiology and the rewriting of life’s grammar
Frontiers in Synthetic BiologyThis study refines Konrad Lorenz’s concept of “natural transcendentalism” by drawing a fundamental distinction between the genetic code and the genome, and by exploring the philosophical consequences of that distinction. I argue that the genetic code can
Nediljko Budisa
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The Platonic Receptacle (Hypodoché), Whitehead’s Philosophy, and Genome Evolution
Viruses, 2017 The discovery of a universal genetic code utilized by all existing organisms became the backbone of biology. The coding capacity underwent changes during evolution, but its main fluctuation results from its different reading and regulation.
Jan Svoboda, Jan Svoboda
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, 2008 textOver the last twenty years, the expansion of the genetic code has been made possible by the encoding of unnatural amino acids into proteins. Unnatural amino acids could be used to expand the chemical functionalities available to biology allowing for ...
Hughes, Randall Allen, 1978-
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
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Understanding the Genetic Code [PDF]
Journal of Bacteriology, 2019 The universal triple-nucleotide genetic code is often viewed as a given, randomly selected through evolution. However, as summarized in this article, many observations and deductions within structural and thermodynamic frameworks help to explain the forces that must have shaped the code during the early evolution of life on Earth.
openaire +4 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
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Augmenting tomato functional genomics with a genome-wide induced genetic variation resource
Frontiers in Plant ScienceInduced mutations accelerate crop improvement by providing novel disease resistance and yield alleles. However, the alleles with no perceptible phenotype but have an altered function remain hidden in mutagenized plants.
Prateek Gupta +6 more
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Quality Control During Aminoacyl-tRNA Synthesis [PDF]
Kemija u Industriji, 2006 The fidelity of translation is determined at two major points: the accuracy of aminoacyl-tRNA selection by the ribosomes and synthesis of cognate amino acid/tRNA pairs by aminoacyl-tRNA synthetases (aaRSs) in the course of the aminoacylation reaction ...
Wang, S. +7 more
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, 2008 YesIn this paper, a simple folded loop antenna (FLA) for handsets with relatively wide- band impedance, designed and optimized using genetic algorithms (GA). The FLA dimensions were optimized and evaluated using GA in collaboration with NEC-2 source code.
Abd-Alhameed, Raed +2 more
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