Results 81 to 90 of about 2,389 (119)
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Optimization and the genetic code
Origins of life and evolution of the biosphere, 1989The present paper will focus on the relation between the structure of the table of the genetic code and the evolution of primitive organisms: it will be shown that the organization of the code table according to an optimization principle based on the notion of resistance to errors can provide a criterium for selection. The ordered aspect of the genetic
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Annual Review of Biophysics and Biomolecular Structure, 2006
Recently, a general method was developed that makes it possible to genetically encode unnatural amino acids with diverse physical, chemical, or biological properties in Escherichia coli, yeast, and mammalian cells. More than 30 unnatural amino acids have been incorporated into proteins with high fidelity and efficiency by means of a unique codon and ...
Lei, Wang +2 more
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Recently, a general method was developed that makes it possible to genetically encode unnatural amino acids with diverse physical, chemical, or biological properties in Escherichia coli, yeast, and mammalian cells. More than 30 unnatural amino acids have been incorporated into proteins with high fidelity and efficiency by means of a unique codon and ...
Lei, Wang +2 more
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The origin of the genetic code
Biochemical and Biophysical Research Communications, 1970Abstract The codons of the genetic code would be expected to participate in the adsorption sites selecting amino acids for reaction with tRNA. A codon-anticodon site shows good correlation with corresponding amino acid structures. It seems therefore probable that the genetic code originated in an evolutionary replacement of a part of an amino acid ...
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The genetic code is not universal
BioSystemsRecently, a new genetic code with 62 sense codons, coding for 21 amino acids, and only 2 termination codons has been identified in archaea. The authors argue that the appearance of this variant of the genetic code is due to the relatively recent and complete recoding of all UAG stop codons to codons encoding for pyrrolysine.
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Scientific American, 1963
This article describes how combinations of bases, or code letters, provide the information used by cells to construct proteins from twenty common kinds of amino acids. Nirenberg recounts recent developments in the field of genetics and illustrates the components and structure of DNA and RNA, and the process of protein synthesis.
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This article describes how combinations of bases, or code letters, provide the information used by cells to construct proteins from twenty common kinds of amino acids. Nirenberg recounts recent developments in the field of genetics and illustrates the components and structure of DNA and RNA, and the process of protein synthesis.
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Trends in Genetics, 2004
More than 30 novel amino acids have been genetically encoded in response to unique triplet and quadruplet codons including fluorescent, photoreactive and redox active amino acids, glycosylated and heavy atom derived amino acids in addition to those with keto, azido and acetylenic chains.
T Ashton, Cropp, Peter G, Schultz
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More than 30 novel amino acids have been genetically encoded in response to unique triplet and quadruplet codons including fluorescent, photoreactive and redox active amino acids, glycosylated and heavy atom derived amino acids in addition to those with keto, azido and acetylenic chains.
T Ashton, Cropp, Peter G, Schultz
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Biochimica et Biophysica Acta (BBA) - General Subjects, 2017
In December of 1966 the last nucleotide triplet in the genetic code has been assigned (Brenner et al., 1967 [1]) thus completing years of studies aimed at deciphering the nature of the relationship between the sequences of genes and proteins. The end product, the table of the genetic code, was a crowning achievement of the quest to unravel the basic ...
Maciej, Szymanski, Jan, Barciszewski
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In December of 1966 the last nucleotide triplet in the genetic code has been assigned (Brenner et al., 1967 [1]) thus completing years of studies aimed at deciphering the nature of the relationship between the sequences of genes and proteins. The end product, the table of the genetic code, was a crowning achievement of the quest to unravel the basic ...
Maciej, Szymanski, Jan, Barciszewski
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Nature, 2016
Gene exploration is providing unexpected insights into inflammatory bowel disease, and getting scientists closer to finding treatments that target the biological mechanisms.
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Gene exploration is providing unexpected insights into inflammatory bowel disease, and getting scientists closer to finding treatments that target the biological mechanisms.
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Collinearity and the genetic code
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966Abstract Modern knowledge of the mechanism of expression of genes derives from the idea, formulated by Beadle in 1945, that each gene determines the structure of a specific protein At that time, this was all that could be said since very little was known about the chemical structure of genes and proteins and nothing about their ...
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Engineering of the genetic code
Current Opinion in BiotechnologyThe genetic code is a universally conserved mechanism that translates genetic information into proteins, consisting of 64 codons formed by four nucleotide bases. With a few exceptions, the genetic code universally encodes 20 canonical amino acids (AAs) and three stop signals, with many AAs represented by multiple codons.
Yael Cohen, Lital Alfonta
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