Results 71 to 80 of about 2,389 (119)

Reprogramming the genetic code

Nature Reviews Genetics, 2020
The encoded biosynthesis of proteins provides the ultimate paradigm for high-fidelity synthesis of long polymers of defined sequence and composition, but it is limited to polymerizing the canonical amino acids. Recent advances have built on genetic code expansion - which commonly permits the cellular incorporation of one type of non-canonical amino ...
Daniel de la Torre, Jason W. Chin
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Genetics and the Origin of the Genetic Code

Origins of Life, 1974
The genetic code has been analysed by a method similar to that used by Gregor Mendel. The current codon catalogue is shown to be symmetrically subdivisible into two discrete subcatalogues of eight quartets each by classifying the quartets as monocoding (for one amino acid only) vs heterocoding (for two amino acids or for amino acid plus nonsense).
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Phylogeny of genetic codes and punctuation codes within genetic codes

Biosystems, 2015
Punctuation codons (starts, stops) delimit genes, reflect translation apparatus properties. Most codon reassignments involve punctuation. Here two complementary approaches classify natural genetic codes: (A) properties of amino acids assigned to codons (classical phylogeny), coding stops as X (A1, antitermination/suppressor tRNAs insert unknown ...
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An expanding genetic code

Methods, 2005
A general method was recently developed that makes it possible to genetically encode unnatural amino acids (UAAs) with diverse physical, chemical or biological properties in Escherichia coli, yeast, and mammalian cells. Over 30 UAAs have been cotranslationally incorporated into proteins with high fidelity and efficiency by means of a unique codon and ...
Jianming, Xie, Peter G, Schultz
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Rewriting the genetic code

Science, 2021
Making room in the genetic code allows the creation of designer proteins with new building ...
Delilah, Jewel, Abhishek, Chatterjee
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On the Origin of the Genetic Code

Journal of Theoretical Biology, 1992
The main theories which have been suggested to explain the origin of genetic code organization are discussed. The coevolution theory, which considers the genetic code as a map of the biosynthetic relationships between amino acids, seems to be based on a mechanism that links it closely to certain stages of the origin of metabolism, which makes it ...
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Expanding The Genetic Code

2017
Protein design is usually limited to 20 amino acids. Since the chemical abilities of these amino acids are limited, a lot of interesting functions are not applicable in protein design. We aim to enable the translational incorporation of non-canonical amino acids (ncAAs) through an expanded genetic code.
Karsten, Lennard, Bergen, Daniel, Drake, Christina, Dymek, Saskia, Edich, Maximillian, Haak, Markus, Kerkhoff, Denise, Kerkhoff, Yannic, Liebers, Michelle, März, Camilla, Schlüter, Laura, Schmidt, Olga, Vinke, Svenja, Whitford, Christopher, Pucker, Boas, Droste, Julian, Rückert, Christian, Müller, Kristian, Kalinowski, Jörn   +18 more
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Stereospecificity of the genetic code

Journal of Molecular Evolution, 1974
A sterical correlation of the amino acids to their anticodon nucleotides is given. The main principle is the intercalation of the amino acid and the binding of the aliphatic amino acid hydrogen atoms through hydrogen bonds to the π-electrons of the bases.
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The genetic code and cyclic codes.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1983
We proposed previously a cyclic code made of 22 triplets, which we now call the AB code. It is made up of the following chain: AUGGUGCCAUUCAAGACUAUGA. The letters A, U, C, G represent the classical symbols of the (purine and pyrimidine) bases of the genetic code.
J, Demongeot, J, Besson
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The evolution of the genetic code

Biochimie, 1976
Summary A Model is described for the evolution of proteins within organisms in the primitive environment. The model is then used to show which chemical and biological properties of the amino acids could have been important in the evolution of the genetic code.
R P, Jorré, R N, Curnow
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