Results 131 to 140 of about 269,589 (261)

Assessing genetic conservation of human sociability-linked genes in C. elegans. [PDF]

Behav Genet
Roozen MC, Kas MJH.
europepmc   +1 more source

Comparison of a Modern and Fossil Pithovirus Reveals Its Genetic Conservation and Evolution. [PDF]

Genome Biol Evol, 2016
Levasseur A, Andreani J, Delerce J, Bou Khalil J, Robert C, La Scola B, Raoult D.   +6 more
europepmc   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Genetic Conservation and Population Management of Non-Human Primates: Parentage Determination Using Seven Microsatellite-Based Multiplexes. [PDF]

Ecol Evol
de Groot NG, de Vos-Rouweler AJM, Heijmans CMC, Louwerse A, Massen JJM, Langermans JAM, Bontrop RE, Bruijnesteijn J.   +7 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Genetic Conservation and Diversity of SARS-CoV-2 Envelope Gene Across Variants of Concern. [PDF]

J Med Virol
Liu BM, Yao Q, Cruz-Cosme R, Yarbrough C, Draper K, Suslovic W, Muhammad I, Contes KM, Hillyard DR, Teng S, Tang Q.   +10 more
europepmc   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

A Community-Based Framework Integrates Interspecific Interactions into Forest Genetic Conservation. [PDF]

Plants (Basel)
Wang X, Xiao Y, Lv YW, He ZH, Yeh FC, Hu XS.   +5 more
europepmc   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Assessment of genetic conservation units of an endangered glacial relict insular species, Amentotaxus formosana, based on fine-scale genetic structures of multiple fragmented mountainous populations in Taiwan. [PDF]

Front Plant Sci
Ko YZ, Shih HC, Ho CS, Chen CT, Hsu TW, Shiao MS, Chiang YC.   +6 more
europepmc   +1 more source