Results 131 to 140 of about 4,605,118 (350)

An integrated map of genetic variation from 1,092 human genomes

open access: yesNature, 2012
By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease.
Gil A. David M. Richard M. Gonçalo R. David R. Aravind McVean Altshuler (Co-Chair) Durbin (Co-Chair) Abec   +499 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Influence of ethylene glycol on Eucalyptus grandis cryopreservation using the V cryo-plate technique

open access: yesCrop Breeding and Applied Biotechnology, 2022
The conservation of plant genetic resources is fundamental for the development of agriculture. The development of efficient cryopreservation protocols has become an effective tool to preserve cells, tissues and organs of different plant species.
Rafaeli Aparecida Vieira de Souza   +3 more
doaj  

Gender, Local Knowledge, and Lessons Learnt in Documenting and Conserving Agrobiodiversity [PDF]

open access: yes
gender, biodiversity, agrobiodiversity, indigenous knowledge, conservation, sustainable management ...
Lambrou, Yianna, Laub, Regina
core  

Insights into a long life without cancer: The case of the bowhead whale

open access: yesMolecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

The costs of breed reconstruction from cryopreserved material in mammalian livestock species

open access: yesGenetics Selection Evolution, 2007
The aim of this work was to compare costs, in the horse, cattle, sheep, swine, and rabbit species, for the creation of gene banks for reconstruction of an extinct breed, using different strategies: embryos-only, embryos in combination with semen, and ...
Gandini Gustavo   +3 more
doaj   +1 more source

Determinants of cereal diversity in communities and on household farms of the Northern Ethiopian Highlands: [PDF]

open access: yes
"On farm conservation of crop diversity poses obvious policy challenges in terms of the design of appropriate incentive mechanisms and possible trade-offs between conservation and productivity.
Benin, Samuel   +4 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Consultation on fish genetic resources [PDF]

open access: yes
Naturally occurring fish genetic resources are of great importance for fisheries and aquaculture. Fish farmers and fishers face a future in which the diversity of their basic resources is under threat and the genetic composition of these resources will ...
Casal, C.M.V. (eds.), Pullin, R.S.V.
core  

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