Results 141 to 150 of about 282,227 (261)

Assessing genetic conservation of human sociability-linked genes in C. elegans. [PDF]

Behav Genet
Roozen MC, Kas MJH.
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Genetic Conservation and Population Management of Non-Human Primates: Parentage Determination Using Seven Microsatellite-Based Multiplexes. [PDF]

Ecol Evol
de Groot NG, de Vos-Rouweler AJM, Heijmans CMC, Louwerse A, Massen JJM, Langermans JAM, Bontrop RE, Bruijnesteijn J.   +7 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Genetic Conservation and Diversity of SARS-CoV-2 Envelope Gene Across Variants of Concern. [PDF]

J Med Virol
Liu BM, Yao Q, Cruz-Cosme R, Yarbrough C, Draper K, Suslovic W, Muhammad I, Contes KM, Hillyard DR, Teng S, Tang Q.   +10 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

A Community-Based Framework Integrates Interspecific Interactions into Forest Genetic Conservation. [PDF]

Plants (Basel)
Wang X, Xiao Y, Lv YW, He ZH, Yeh FC, Hu XS.   +5 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Assessment of genetic conservation units of an endangered glacial relict insular species, <i>Amentotaxus formosana</i>, based on fine-scale genetic structures of multiple fragmented mountainous populations in Taiwan. [PDF]

Front Plant Sci
Ko YZ, Shih HC, Ho CS, Chen CT, Hsu TW, Shiao MS, Chiang YC.   +6 more
europepmc   +1 more source

The Genetics of Conservation [PDF]

BioScience, 2018
openaire   +1 more source