Results 71 to 80 of about 269,589 (261)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pomar de sementes por mudas a partir da seleção dentro em teste de progênies de Myracrodruon urundeuva Fr. All. Seedling seed-orchard from selection within progenies of Myracrodruon urundeuva Fr. All. [PDF]

Revista do Instituto Florestal, 2007
A conservação genética de espéciesarbóreas é fundamental para que as futurasgerações possam usufruir os recursos fornecidosatualmente por estas espécies.
Miguel Luiz Menezes FREITAS, Alexandre Magno SEBBENN, Antonio Carlos Scatena ZANATTO, Eurípedes MORAES   +3 more
doaj  

Population structure, fluctuating asymmetry and genetic variability in an endemic and highly isolated Astyanax fish population (Characidae)

Genetics and Molecular Biology, 2004
Morphological and chromosomal markers were used to infer the structure and genetic variability of a population of fish of the genus Astyanax, geographically isolated at sinkhole 2 of Vila Velha State Park, Paraná, Brazil.
Maria Claudia Gross, Carlos Henrique Schneider, Mara Cristina de Almeida Matiello, Maysa de Lima Leite, Luiz Antonio Carlos Bertollo, Roberto Ferreira Artoni   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Variação genética para caracteres quantitativos em população de Gallesia integrifolia (Spreng.) Harms. Genetic variation for quantitative traits in Gallesia integrifolia (Spreng.) Harms. Population. [PDF]

Revista do Instituto Florestal, 2008
Este estudo avaliou a variação genéticapara os caracteres quantitativos crescimento,sobrevivência e forma do fuste em um teste deprogênies de Gallesia integrifolia procedente deAlvorada do Sul (PR), na Estação Experimentalde Luiz Antônio (SP). O teste de
Eurípedes MORAES, Antonio Carlos Scatena ZANATTO, Alexandre Magno SEBBENN, Miguel Luiz Menezes FREITAS, Marcela Aparecida de MORAES   +4 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Demographic Analysis of Sixteen Iberian Sheep Breeds Based on Pedigree Data

Biology
The Iberian Peninsula hosts a rich diversity of sheep genetic resources shaped by contrasting environments, historical management practices, and varying levels of endangerment.
Laura Marín Marín, Nuno Carolino, María Esperanza Camacho Vallejo, José Ignacio Salgado Pardo, Juan Vicente Delgado Bermejo, José Manuel León Jurado, Esther Díaz Ruiz, Eugenio Espinosa de los Monteros Jaúdenes, José Antonio Puntas Tejero, Manuel Aguilera Ropero, Águeda Laura Pons Barro, José Manuel Alanzor Puente, Sergio Nogales Baena, Claudino Matos, José Rodrigues, Tiago Perloiro, Sara Roque, Maria Inês Carolino, Andreia Vitorino, Antonio González Ariza   +19 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source