Results 51 to 60 of about 268,910 (261)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Profiles and roles of N6-methyladenosine modification in bovine oocyte maturation

BMC Genomics
Background Bovine oocyte quality is crucial for successful in vitro embryo production; therefore, elucidating the mechanisms underlying oocyte maturation is essential.
Tiancang Han, Zhichao Wang, Xinqi Gan, Zhiyuan Yang, Wenzhuo Wang, Kunlong Hu, Ruiqing Zhu, Yunsheng Li, Yunhai Zhang, Zubing Cao   +9 more
doaj   +1 more source

Shotgun Sequencing for Microsatellite Identification in Ilex paraguariensis (Aquifoliaceae)

Applications in Plant Sciences, 2013
Premise of the study: Ilex paraguariensis is a native tree species from Brazil, Argentina, and Paraguay that is used in the production of beverages, medicines, and cosmetics.
Marlei F. Pereira, Ana Y. Ciampi, Peter W. Inglis, Valderês A. Souza, Vânia C. R. Azevedo   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Differentiation measures for conservation genetics [PDF]

Evolutionary Applications, 2018
AbstractWe compare the two main classes of measures of population structure in genetics: (i) fixation measures such as FST, GST, and θ and (ii) allelic differentiation measures such as Jost's D and entropy differentiation. These two groups of measures quantify complementary aspects of population structure, which have no necessary relationship with each
Lou Jost, Frederick Archer, Sarah Flanagan, Oscar Gaggiotti, Sean Hoban, Emily Latch   +5 more
openaire   +4 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Genetic diversity of Piracanjuba populations in fish stocking programs in the Tietê River, Brazil

Revista Colombiana de Ciencias Pecuarias, 2019
Background: Piracanjuba (Brycon orbignyanus) is a fish species highly affected by anthropogenic actions such as overfishing, water pollution, and hydroelectric developments. This species is currently considered in danger of extinction.
Nelson M. Lopera-Barrero, Silvio C. A. Santos, Pedro L. Castro, Felipe P. Souza, Angela R. Poveda-Parra, Victor C. F. Pandolfi, Andrei L. Yamachita, Angela M. Urrea-Rojas, Diego A. Rojas-Meza, Ricardo P. Ribeiro   +9 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

A diversidade dos recursos genéticos vegetais e a nova pesquisa agrícola The diversity of plant genetic resources and the new approaches in the agronomic research

Ciência Rural, 1998
As novas demandas da pesquisa agrícola requerem a formação de recursos humanos com níveis avançados de qualificação e capazes de elaborar e executar propostas científicas, tecnológicas e políticas relacionadas ao uso, melhoramento e conservação dos ...
Miguel Pedro Guerra, Rubens Onofre Nodari, Maurício Sedrez dos Reis, Afonso Inácio Orth   +3 more
doaj   +1 more source