Results 181 to 190 of about 1,122,121 (342)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Genetic correlation between chronic sinusitis and autoimmune diseases. [PDF]

Front Allergy
Wang E, Sun Y, Zhao H, Wang M, Cao Z.
europepmc   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Genetic correlation and mendelian randomization reveal the impact of sleep traits on urolithiasis risk. [PDF]

Sci Rep
Yan M, Zhang ZX, Hu JX, Wang KB, Liu CY.
europepmc   +1 more source

Determination of genetic correlation between tobacco smoking and coronary artery disease. [PDF]

Front Psychiatry, 2023
Zhu Z, Liu Q, Li M, Yao Y, Qi F, Xu Y, Lu S, Yang Z, Guan Y, Li MD, Yao J.   +10 more
europepmc   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Accelerating Heritability, Genetic Correlation, and Genome-Wide Association Imaging Genetic Analyses in Complex Pedigrees. [PDF]

Hum Brain Mapp
Donohue B, Gao S, Nichols TE, Adhikari BM, Ma Y, Jahanshad N, Thompson PM, McMahon FJ, Humphries EM, Burroughs W, Ament SA, Mitchell BD, Ma T, Chen S, Medland SE, Blangero J, Hong LE, Kochunov P.   +17 more
europepmc   +1 more source

Genetic correlation between aggressive signals and fighting. [PDF]

Biol Lett, 2023
Baxter CM, Shams I, Dworkin I, Dukas R.
europepmc   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization. [PDF]

Sci Rep
Ding L, Chen B, Zhou Z, Mei Z, Cao K, Lu X, Chen W.   +6 more
europepmc   +1 more source