Results 201 to 210 of about 1,008,628 (263)

Genetic correlation and mendelian randomization reveal the impact of sleep traits on urolithiasis risk. [PDF]

Sci Rep
Yan M, Zhang ZX, Hu JX, Wang KB, Liu CY.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Rheumatoid arthritis and risk of hearing impairment: A genetic correlation and bidirectional Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liu Z, Xiang G, Wang L, Duan L, Guo P.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Disentangling Perinatal Depression from General Major Depression: A GWAS Meta-Analysis and Genetic Correlation Approach in European Datasets

Maina JG, Guintivano J, Wang R, Meldrum L, Kakar S, Li D, Lee S, Davies HL, Kalsi G, Cleare AJ, Davis KA, Walters JT, Smith DJ, Armour C, McIntosh A, Kingston N, Bradley JR, The GLAD Study, NIHR BioResource Consortium, Hotopf M, Vassos E, Coleman JR, Eley T, Breen G.   +23 more
europepmc   +1 more source

Causal Relationship Between Blood Metabolites and Osteoporosis: A Two-Sample Mendelian Randomization and Genetic Correlation Analysis. [PDF]

Bioengineering (Basel)
Liu X, Yang G, Li Y, Xiao W, Lu B, Wang Y.   +5 more
europepmc   +1 more source

Accelerating Heritability, Genetic Correlation, and Genome-Wide Association Imaging Genetic Analyses in Complex Pedigrees. [PDF]

Hum Brain Mapp
Donohue B, Gao S, Nichols TE, Adhikari BM, Ma Y, Jahanshad N, Thompson PM, McMahon FJ, Humphries EM, Burroughs W, Ament SA, Mitchell BD, Ma T, Chen S, Medland SE, Blangero J, Hong LE, Kochunov P.   +17 more
europepmc   +1 more source

Blood Pressure, Cardiometabolic Traits, and Cardiovascular Events in Women With Uterine Fibroids: A Genetic Correlation and Mendelian Randomization Study. [PDF]

J Am Heart Assoc
Henry J, Berrandou T, Brewster LM, Bouatia-Naji N.   +3 more
europepmc   +1 more source

Causal associations of interleukins and osteoporosis: A genetic correlation study. [PDF]

Medicine (Baltimore)
Chen H, Lin H, Dai J.
europepmc   +1 more source