Results 11 to 20 of about 1,753,758 (209)

Gene-history correlation and population structure

, 2004
Correlation of gene histories in the human genome determines the patterns of genetic variation (haplotype structure) and is crucial to understanding genetic factors in common diseases.
Eriksson A Mehlig B, Griffiths R C, Griffiths R C, Hill W G, Hudson P R, Hudson R, Hudson R R, Hudson R R, Kaplan N, Kong A, Kuhner M K, McPeek M S, McVean G, McVean G, Nielsen R, Pluzhnikov A, Slatkin M, Tajima F, Tajima F   +18 more
core   +2 more sources

Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. [PDF]

, 2011
Considerable attention has been paid to identifying genetic influences and gene-environment interactions that increase vulnerability to environmental stressors, with promising but inconsistent results.
Bailey, JN, Breidenthal, SE, Fairbanks, LA, Jorgensen, MJ, Kaplan, JR, Laudenslager, ML   +5 more
core   +1 more source

Population and species neighbor identity impact trait–trait relationships and plant performance

Population Ecology, EarlyView.
We evaluated how populations and species identity influence plant performance and trait outcomes in mixtures, and assessed trait variation among populations of two forb species native to the western United States (Dieteria canescens and Heterotheca villosa) following three interaction treatments (single‐population monoculture, two‐population mixture ...
Alicia J. Foxx, Florian Fort, Andrea T. Kramer   +2 more
wiley   +1 more source

Effects of chronic browsing on life‐history traits of an irruptive large herbivore population

Population Ecology, EarlyView.
This study aimed to determine the relationship between diet quality, body mass, and size (hind foot length), and female reproduction and sought to identify the mechanism by which high density under severe food limitations is maintained. Our results demonstrated that sika deer introduced to Nakanoshima Island have maintained high densities through high ...
Koichi Kaji, Kazutaka M. Takeshita, Hiroshi Takahashi, Hiromasa Igota, Mayumi Ueno, Yukiko Matsuura, Takashi Ikeda, Ryo Yoshizawa, Hino Takafumi, Tsuyoshi Yoshida   +9 more
wiley   +1 more source

Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]

, 2017
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro, Masui, Kenta, Mischel, Paul S, Sawada, Tatsuo, Shibata, Noriyuki   +4 more
core   +2 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Isolation by distance in a population of a small land snail Trochoidea geyeri : evidence from direct and indirect methods [PDF]

, 2006
Population structure was estimated in a continuous population of a small land snail (Trochoidea geyeri). Mark-recapture experiments and randomly amplified polymorphic DNA analyses indicate that the population structure can be described by the isolation ...
Bahl, Andreas, Pfenninger, Markus, Streit, Bruno   +2 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Estimation of Genetic Parameters for Peak Yield, Yield and Persistency Traits in Murciano-Granadina Goats Using Multi-Traits Models [PDF]

, 2019
This paper studies parameters of a lactation curve such as peak yield (PY) and persistency (P), which do not conform to the usual selection criteria in the Murciano-Granadina (MG) breed, but are considered to be an alternative to benefit animal welfare ...
Barba Capote, C.J., Gómez Carpio, Mayra Mercedes, León Jurado, J.M., Miranda, Judith C., Pieramati, C., Valdés, Jesús   +5 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source