Results 41 to 50 of about 1,008,628 (263)

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Heritability of problem drinking and the genetic overlap with personality in a general population sample

Frontiers in Genetics, 2011
This study examined the heritability of problem drinking and investigated the phenotypic and genetic relationships between problem drinking and personality. It was conducted in a sample of 5,870 twins and siblings and 4,420 additional family members from
Marleen H.M. De Moor, Marleen H.M. De Moor, Jacqueline M. Vink, Jacqueline M. Vink, Jenny H.D.A. van Beek, Jenny H.D.A. van Beek, Lot M. Geels, Lot M. Geels, Meike eBartels, Meike eBartels, Meike eBartels, Eco J.C. de Geus, Eco J.C. de Geus, Eco J.C. de Geus, Gonneke eWillemsen, Gonneke eWillemsen, Gonneke eWillemsen, Dorret I. Boomsma, Dorret I. Boomsma, Dorret I. Boomsma   +19 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Estimating heritability in honeybees: Comparison of three major methods based on empirical and simulated datasets

Ecology and Evolution, 2021
The genetic contribution to phenotypic variation (namely the heritability) affects the response to selection. In honeybee, the haplodiploid sex determination does not allow the straightforward use of classical quantitative genetics methods to estimate ...
Hélène Jourdan‐Pineau, Gaëlle Antoine, Julien Galataud, Hélène Delatte, Christophe Simiand, Johanna Clémencet   +5 more
doaj   +1 more source

Estimates of Genetic Parameters for Milk, the Occurrence of and Susceptibility to Clinical Lameness and Claw Disorders in Dairy Goats

Animals, 2023
The New Zealand goat industry accesses niche markets for high-value products, mainly formula for infants and young children. This study aimed to estimate the genetic parameters of occurrence and susceptibility of clinical lameness and selected claw ...
Natasha Jaques, Sally-Anne Turner, Emilie Vallée, Cord Heuer, Nicolas Lopez-Villalobos   +4 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Genetic Analysis of Cortical Thickness and Fractional Anisotropy of Water Diffusion in the Brain

Frontiers in Neuroscience, 2011
ObjectivesThe thickness of the brain’s cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age.
Peter eKochunov, Peter eKochunov, Peter eKochunov, David eGlahn, David eGlahn, Tom eNichols, Anderson eWinkler, Elliott eHong, Henry eHolcomb, Jason eStein, Paul eThompson, Joanne eCurran, Melany eCarless, Rene eOlvera, MP eJohnson, Shelley eCole, Valeria eKochunov, Jack eKent, John eBlangero   +18 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Hot and Cold Nociception Are Genetically Correlated [PDF]

The Journal of Neuroscience, 1999
Recent experiments in our laboratory have revealed a genetic correlation of the sensitivity of inbred mouse strains to different assays of nociception using noxious heat stimuli. An open question is whether the property of the noxious stimulus underlying the genetic correlation is heat specifically or simply a temperature (hot or cold) in the noxious ...
J S, Mogil, S M, Adhikari
openaire   +2 more sources

Estimation of genetic parameters for milking temperament in Holstein-Gyr cows

Frontiers in Animal Science, 2023
IntroductionDairy cattle with poor temperament can cause several inconveniences during milking, leading to labor difficulties, increasing the risk of accidents with animals and workers, and compromising milk yield and quality.
Paula A. Batista Taborda, Paula A. Batista Taborda, Tiago da Silva Valente, Monique Valéria de Lima Carvalhal, Marcos Vinicius Gualberto Barbosa da Silva, Mateus J. R. Paranhos da Costa   +5 more
doaj   +1 more source