Results 71 to 80 of about 7,495,262 (331)

Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders

JAMA psychiatry, 2023
Key Points Question To what extent are shared genetic determinants in the comorbidities and associations between gastrointestinal tract diseases and psychiatry disorders involved in the gut-brain axis? Findings In this genome-wide pleiotropic association
Weiming Gong, Ping Guo, Yuanming Li, Lu Liu, Ran Yan, Shu Liu, Shukang Wang, F. Xue, Xiang Zhou, Zhongshang Yuan   +9 more
semanticscholar   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Variance components estimation for type traits in Slovenian Brown Swiss cattle

Acta Agriculturae Slovenica, 2012
The objective of this study was to estimate genetic parameters for 39 (26 official and 13 new) scored type traits in Slovenian Brown Swiss cattle. Data set included records of 35 386 Brown Swiss cows scored from 2000 to 2011 using method ‘System 97’. The
Marija ŠPEHAR, Miran ŠTEPEC, Klemen POTOČNIK   +2 more
doaj   +1 more source

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Improving genetic prediction by leveraging genetic correlations among human diseases and traits

Nature Communications, 2018
Genomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to demonstrate that widespread pleiotropy
Robert M. Maier, Zhihong Zhu, S. Lee, M. Trzaskowski, D. Ruderfer, E. Stahl, S. Ripke, N. Wray, Jian Yang, P. Visscher, M. Robinson   +10 more
semanticscholar   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Study on Correlation between Hb and Tf Locus Genotypes and Some Milk Yield Traits within a Gray Steppe Cattle Population

Scientific Papers Animal Science and Biotechnologies, 2023
Having considered the importance of genetic polymorphism of biochemical structures we considered a study of the genetic characterization of a sample in a cattle population, based on the information offered by the genetic polymorphism at hemoglobin and ...
Nicoleta Isfan, Dana Popa, Dan Colceri, Sergiu Georgescu, Razvan Popa, Cristina Pirvulet, Carmen Nicolae, Marius Maftei   +7 more
doaj  

Symptoms of major depression: Their stability, familiality, and prediction by genetic, temperamental, and childhood environmental risk factors [PDF]

, 2017
Background: Psychiatry has long sought to develop biological diagnostic subtypes based on symptomatic differences. This effort assumes that symptoms reflect, with good fidelity, underlying etiological processes.
Aggen, Steven H., Kendler, Kenneth S.
core   +2 more sources

Evidence for Genetic Correlations and Bidirectional, Causal Effects Between Smoking and Sleep Behaviors

bioRxiv, 2018
Introduction Cigarette smokers are at increased risk of poor sleep behaviours. However, it is largely unknown whether these associations are due to shared (genetic) risk factors and/or causal effects (which may be bi-directional).
M. Gibson, M. Munafo, Amy E Taylor, J. Treur   +3 more
semanticscholar   +1 more source

Parent‐to‐Child Information Disclosure in Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite professional consensus regarding the importance of open communication with pediatric cancer patients about their disease, actual practice patterns of disclosure are understudied. Extant literature suggests a significant proportion of children are not told about their diagnosis/prognosis, which is purported to negatively ...
Rachel A. Kentor, Flora Hoodin, Michelle Byrd, Kristin A. Kullgren, Leah LaLonde, Lauren Benkoske, Patrick Smith, Dawn Carson, Karen MacDonald, Susumu Inoue, Brenda Kitchen, Kate Gowans, Gregory A. Yanik   +12 more
wiley   +1 more source