Results 141 to 150 of about 3,117,325 (331)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Genetic Counseling and Presenilin-1 Alzheimer's Disease: “Research Family” Members Share Some Thoughts [PDF]

, 2007
Linda E. Nee
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

P551: Implementing next-generation sequencing as part of newborn screening in state public health laboratories: Status and barriers

Genetics in Medicine Open
Margaux Haiber, Christine Seymour, Kristen Sund, Holly Snyder   +3 more
doaj   +1 more source

Developing a short-form of the Genetic Counselling Outcome Scale: The Genomics Outcome Scale

, 2018
Peter E. Grant, María Pampaka, Katherine Payne, Angus Clarke, Marion McAllister   +4 more
openalex   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Communicating risk and the landscape of cancer prevention — an exploratory study that examines perceptions of cancer-related genetic counseling and testing among African Americans and Latinos in the Midwest [PDF]

, 2023
Crystal Y. Lumpkins, Rafaela Nelson, Zawadi Twizele, Mariana Ramírez, Kim S. Kimminau, Alisdair R. Philp, Reem A. Mustafa, Andrew K. Godwin   +7 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

P617: Utility of negative fetal exome sequencing in diagnosing chondrodysplasia punctata associated with maternal systemic lupus erythematosus: A case report

Genetics in Medicine Open, 2023
Christina Miller, Kestutis Micke
doaj   +1 more source

Genesurance Counseling: Genetic Counselors’ Roles and Responsibilities in Regards to Genetic Insurance and Financial Topics [PDF]

, 2017
Shelby Brown, Susan E. Puumala, Jennifer Leonhard, Megan Bell, Jason Flanagan, Lori Williamson Dean, Quinn Stein   +6 more
openalex   +1 more source