Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
Fundamentos clínicos del consejo genético en cáncer hereditario
Psicooncologia, 2005 We describe the Genetic Counseling as the translation of the hereditary cancer knowledge to the clinical practice. Genetic counseling is a process for information, which takes place at the Genetic Counseling Units, where individual cancer risk and ...
Ana López +8 more
doaj
STAMPsy: Towards SpatioTemporal-Aware Mixed-Type Dialogues for Psychological Counseling [PDF]
arXivOnline psychological counseling dialogue systems are trending, offering a convenient and accessible alternative to traditional in-person therapy. However, existing psychological counseling dialogue systems mainly focus on basic empathetic dialogue or QA with minimal professional knowledge and without goal guidance.
arxiv
In Search of New Perspectives in Cancer Genetics Services: Exploring Use of Genetic Counseling Among a Group of Young Breast Cancer Survivors [PDF]
, 2018 Breast cancer associated with mutations in the breast cancer genes BRCA1 and BRCA2 often occurs at an earlier age and individuals with a mutation have increased risk for developing breast, ovarian, and other cancers. The cancers may be more difficult to
Lee, Cheryl
core
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
Quality-Control Study Evaluating the Identification, Family History Collection, and Genetic Counseling Referral of Individuals At-Risk for HNPCC (Lynch Syndrome) Within the University of Pittsburgh Medical Center System and Applications to a State-Wide Referral System [PDF]
, 2012 Background: Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is a dominantly inherited syndrome predisposing individuals to cancers of the colon and other organs.
Sardella, Andrew
core +1 more source
Monozygotic twins discordant for Wiedemann-Beckwith syndrome and the implications for genetic counselling. [PDF]
, 1980 A C Berry, E M Belton, C Chantler
openalex +1 more source
CPsyCoun: A Report-based Multi-turn Dialogue Reconstruction and Evaluation Framework for Chinese Psychological Counseling [PDF]
arXivUsing large language models (LLMs) to assist psychological counseling is a significant but challenging task at present. Attempts have been made on improving empathetic conversations or acting as effective assistants in the treatment with LLMs. However, the existing datasets lack consulting knowledge, resulting in LLMs lacking professional consulting ...
arxiv
Addressing Intimate Partner Violence in Genetics Patient Perspectives on Intimate Partner Violence Discussion and/or Disclosure During Genetic Counseling Sessions [PDF]
, 2016 Intimate partner violence (IPV) is a major health concern that has become a nationwide epidemic in the United States (ACOG, 2013). The World Health Organization (WHO) describes IPV as physical, sexual, psychological harm including physical aggression and
Chen, Christina
core +1 more source