Results 181 to 190 of about 234,175 (326)

Genetic drift acts strongly on within-host influenza virus populations during acute infection but does not act alone [PDF]

Yike Teresa Shi, Michael A. Martin, Daniel B. Weissman, Katia Koelle   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Emergence of circulating influenza A H3N2 viruses with genetic drift in the matrix gene: be alert of false-negative test results. [PDF]

APMIS, 2022
Jørgensen RL, Lerche CJ, Pedersen MS, Kirkby NS, Botnen AB, Trebbien R, Nilsson-Møller S, Pinholt M, Nielsen ACY, Westh H, Lisby JG, Schneider UV.   +11 more
europepmc   +1 more source

A Hands-on Exercise to Demonstrate Evolution by Natural Selection & Genetic Drift [PDF]

, 2003
Helen J. Young, Truman P. Young
openalex   +1 more source

From Understanding Genetic Drift to a Smart-Restart Mechanism for Estimation-of-Distribution Algorithms [PDF]

, 2022
Weijie Zheng, Benjamin Doerr
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A multi-season epidemic model with random genetic drift and transmissibility. [PDF]

J Math Biol
Britton T, Pugliese A.
europepmc   +1 more source

Evolution of flowering time in a selfing annual plant: Roles of adaptation and genetic drift. [PDF]

Ecol Evol, 2022
Gay L, Dhinaut J, Jullien M, Vitalis R, Navascués M, Ranwez V, Ronfort J.   +6 more
europepmc   +1 more source

Additional file 5: Figure S2. of Drift, selection, or migration? Processes affecting genetic differentiation and variation along a latitudinal gradient in an amphibian

, 2017
Maria Cortázar-Chinarro, Ella Lattenkamp, Yvonne Meyer-Lucht, Émilien Luquet, Anssi Laurila, ‎Jacob Höglund   +5 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source