Results 231 to 240 of about 230,882 (281)
Genetic drift versus regional spreading dynamics of COVID-19
, 2020 Pietro RD +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
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Rett syndrome and genetic drift
Brain and Development, 1999An X chromosome gene is assumed to be responsible for the cause of Rett syndrome (RS). However, new genealogical observations suggest involvement of autosomal recessive gene(s) as well, at least in familial cases. To account for these and other recent observations, the theoretical model presented in 1990 by the authors of this paper is applied to the ...
E M, Bühler, N J, Malik, M, Alkan
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Population Genetics: Consanguinity, Genetic Drift
1997Considerations in the preceding chapters presume random mating, and Hardy-Weinberg proportions are assumed to hold true. However, such assumptions are an abstraction. In modern outbreeding populations mating may approximate randomness for some genetic traits, such as blood groups and enzyme types, but is certainly nonrandom for some traits and some ...
Friedrich Vogel, Arno G. Motulsky
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Crop Science, 2003
Many public sector maize recurrent selection programs have been designed based on additive genetic expectations. Populations have been managed as large metapopulations with the assumption that population size must be very large because inbreeding due to finite size causes a linear reduction in genetic variance; we show that in BS13(S)C0 such ...
Jode W. Edwards, Kendall R. Lamkey
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Many public sector maize recurrent selection programs have been designed based on additive genetic expectations. Populations have been managed as large metapopulations with the assumption that population size must be very large because inbreeding due to finite size causes a linear reduction in genetic variance; we show that in BS13(S)C0 such ...
Jode W. Edwards, Kendall R. Lamkey
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Genetic drift in exogamous marriage systems
Theoretical Population Biology, 1975Many mathematical models have been developed to study genetic drift under a variety of assumptions (e.g. Karlin (1968), Crow and Kimura (1970)). Our purpose in this paper is to extend the range of available models by incorporating an additional feature of particular relevance to human populations, to derive certain latent roots for these models, and to
Cannings, C., Skolnick, M. H.
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1980
Random changes are difficult to discuss, in that we cannot (usually) say that some specific change will happen, only that the change is probable or improbable. Statements involving probability are apt to produce discomfort in the reader, a vague sense of entering through a shop door labelled “only abstractions sold here”.
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Random changes are difficult to discuss, in that we cannot (usually) say that some specific change will happen, only that the change is probable or improbable. Statements involving probability are apt to produce discomfort in the reader, a vague sense of entering through a shop door labelled “only abstractions sold here”.
openaire +1 more source
2016
Genetic drift is a random process that can lead to the fixation of alleles, but at the cost of losing alleles, especially those with low frequencies, and to increased homozygosity in the population. This process is described for an idealised population and its effect illustrated on different population sizes.
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Genetic drift is a random process that can lead to the fixation of alleles, but at the cost of losing alleles, especially those with low frequencies, and to increased homozygosity in the population. This process is described for an idealised population and its effect illustrated on different population sizes.
openaire +1 more source