Results 161 to 170 of about 6,955,736 (304)

Special Issue "Genetic Engineering of Plants for Stress Tolerance". [PDF]

Int J Mol Sci
Chen M.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Engineering Vanderbilt; Vol. 53, No. 01, 2012

, 2012
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of Engineering.Vanderbilt University.
Vanderbilt University. School of Engineering
core  

Genetic Engineering of Human Embryonic Stem Cells for Precise Cell Fate Tracing during Human Lineage Development. [PDF]

Stem Cell Reports
Chen Z, Ren X, Xu X, Zhang X, Hui Y, Liu Z, Shi L, Fang Y, Ma L, Liu Y, Terheyden-Keighley D, Liu L, Zhang X.   +12 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Characterisation of T3SS-positive non-pathogenic Pseudomonas strains: plant growth promotion, induced systemic resistance in sugar beet (Beta vulgaris L.) and effector repertoires

The intricate interplay between plants and microorganisms in agricultural ecosystems offers significant opportunities to improve crop productivity and resilience in the context of climate change and increasing pathogen challenges.
Nedeljković, Marija, Lozo, Jelena, Atanasković, Iva, Stanković, Slaviša, Mesaroš, Aleksandra   +4 more
core  

In Situ Genetic Engineering Facilitates MMP-9-Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing. [PDF]

Adv Sci (Weinh)
Zhang Y, Deng J, Cheung MY, Fu T, Qi X, Cai D, Sun J, Lu G, Shi P, Chan WY, Li X, Zhao H.   +11 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Application of the CPER reverse genetics system for genetic engineering of rabies virus. [PDF]

J Virol
Itakura Y, Kawaguchi N, Tabata K, Gonzalez G, Konishi K, Ohnuma A, Furuta I, Ito N, Saito S, Hall WW, Orba Y, Sawa H, Sasaki M.   +12 more
europepmc   +1 more source