Results 41 to 50 of about 5,820,249 (380)
Next generation designer virus-like particle vaccines for dengue
Expert Review of Vaccines, 2019 Introduction: A safe and efficacious vaccine for dengue continues to be an unmet public health need. The recent licensing of a dengue vaccine (Dengvaxia) developed by Sanofi has brought to the fore the safety issue of vaccine-induced infection ...
Rahul Shukla +8 more
doaj +1 more source
Bacterial Genetic Engineering by Means of Recombineering for Reverse Genetics
Frontiers in Microbiology, 2020 Serving a robust platform for reverse genetics enabling the in vivo study of gene functions primarily in enterobacteriaceae, recombineering -or recombination-mediated genetic engineering-represents a powerful and relative straightforward genetic ...
Ursula Fels, K. Gevaert, P. Van Damme
semanticscholar +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Historical and technological development of genetic engineering in Croatia
Studia Lexicographica, 2020 The paper provides an overview of concepts and knowledge about genetic engineering and its development in Croatia and abroad from the second half of the 20th century to the present day.
Vlatka Godinić Mikulčić
doaj +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Dalla creazione alla programmazione. Il concetto di vita nell’era della biologia sintetica [PDF]
S&F_scienzaefilosofia.it, 2014 This paper aims to organize a reflection about the recent developing field of synthetic biology. It is structured into three main parts. The first one tries to point out the features of this emerging field (the analogies and the differences with the ...
Luca Lo Sapio
doaj
Canadian Journal of Infectious Diseases and Medical Microbiology, 2022 Background. Multidrug-resistant (MDR) clones of Klebsiella pneumoniae (Kpn) have been increasingly documented in community-acquired and nosocomial infections all around the globe.
Afroza Akter Tanni +7 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Comparison of Direct Multiobjective Optimization Methods for the Design of Electric Vehicles [PDF]
, 2006 "System design oriented methodologies" are discussed in this paper through the comparison of multiobjective optimization methods applied to heterogeneous devices in electrical engineering.
Fefermann, Yan +3 more
core +2 more sources