Results 81 to 90 of about 723,030 (329)
Engineering design using genetic algorithms [PDF]
, 2007 As modern computational and modeling technologies grow, engineering design heavily relies on computer modeling and simulation to accelerate design cycles and save cost. A complex design problem will involve many design parameters and tables.
Fang, Xiaopeng
core +3 more sources
Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
FEBS Letters, EarlyView.The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine +3 more
wiley +1 more source
Efforts and Challenges in Engineering the Genetic Code
Life, 2017 This year marks the 48th anniversary of Francis Crick’s seminal work on the origin of the genetic code, in which he first proposed the “frozen accident” hypothesis to describe evolutionary selection against changes to the genetic code that cause ...
Xiao Lin +2 more
doaj +1 more source
Amazing geometry of genetic space or are genetic algorithms convergent? [PDF]
arXiv, 2005 There is no proof yet of convergence of Genetic Algorithms. We do not supply it too. Instead, we present some thoughts and arguments to convince the Reader, that Genetic Algorithms are essentially bound for success. For this purpose, we consider only the crossover operators, single- or multiple-point, together with selection procedure.
arxiv
Use of Molecular Genetic Engineering in the Study of Animal Parasites and Their Vectors [PDF]
, 1989 Molecular genetics coupled with advances in immunology and parasite culture has become a powerful tool to study animal parasites and their vectors. Recombinant DNA techniques allow one to identify individual genes of DNA probes, amplify the nucleic acid ...
LoVerde, P. T. (Philip)
core
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
The Triplet Genetic Code had a Doublet Predecessor [PDF]
Journal of Theoretical Biology 233 (2005) 527-532, 2004 Information theoretic analysis of genetic languages indicates that the naturally occurring 20 amino acids and the triplet genetic code arose by duplication of 10 amino acids of class-II and a doublet genetic code having codons NNY and anticodons $\overleftarrow{\rm GNN}$. Evidence for this scenario is presented based on the properties of aminoacyl-tRNA
arxiv
Genetic engineering and trade [PDF]
Advocates of the use of genetic engineering techniques in agriculture contend that this new biotechnology promises increased productivity, better use of natural resources and more nutritious foods.
Nielsen, Chantal Pohl +2 more
core
2D multi-objective placement algorithm for free-form components [PDF]
, 2009 This article presents a generic method to solve 2D multi-objective placement problem for free-form components. The proposed method is a relaxed placement technique combined with an hybrid algorithm based on a genetic algorithm and a separation algorithm.
Bennis, Fouad +3 more
core +2 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source