Results 121 to 130 of about 3,869,150 (303)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Genetic analysis of protein composition of bovine milk [PDF]

open access: yes, 2010
This thesis is part of the Dutch Milk Genomics Initiative, and the general aim was to obtain more insight into the genetic background of bovine milk protein composition.
Schopen, G.C.B.
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Three genetic developmental stages of papillary renal cell tumors: Duplication of chromosome 1q marks fatal progression

open access: yes, 2009
Papillary renal cell tumors (RCT) make up a cytomorphologically and biologically heterogeneous group of kidney cancers including renal cell adenomas (RCA) and renal cell carcinomas (RCC). To find genetic markers landmarking the tumor progression, we have
Szponar, A   +4 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Genetic Gain Performance Metric Accelerates Agricultural Productivity

open access: yes, 2017
The agricultural seed industry invests billions of dollars each year to improve our understanding of how best to unlock a seed’s full potential. This investment brings a significant benefit to agricultural customers—the farmers who grow commodity crops,
Joseph Byrum   +7 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Behaviour and weight gain in early infancy [PDF]

open access: yes, 2000
Slow weight gain in infancy is the core sign of failure to thrive. However, it is far from clear what the cause of the slow weight gain in infancy is. Failure to thrive is mostly identified late in the first year at which time it becomes problematic to ...
Molkenboer, A.E.   +1 more
core  

A dynamic assessment of water scarcity risk in the Lower Brahmaputra River Basin: An integrated approach

open access: yes, 2015
Many international river basins are likely to experience increasing water scarcity over the coming decades. This water scarcity is not rooted only in the limitation of resources, i.e.
Giupponi, C   +5 more
core   +1 more source

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