Results 251 to 260 of about 6,543,071 (370)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Optimal Combination of Different Selection and Mating Strategies on Exploiting Genetic Diversity and Genetic Gain in Small Pig Conservation Populations. [PDF]

J Anim Breed Genet
Zhao Q, Liu H, Zhang Q, Qadri QR, Pan Y, Su G, Li P, Huang R.   +7 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Optimal implementation of genomic selection in clone breeding programs exemplified in potato: II. Effect of selection strategy and cross-selection method on long-term genetic gain. [PDF]

Plant Genome
Wu PY, Stich B, Hartje S, Muders K, Prigge V, Van Inghelandt D.   +5 more
europepmc   +1 more source

Genetic evaluation and genetic gains with the selection for Jatropha curcas populations

, 2010
This work aimed at estimating genetic parameters from the vegetative stage in five populations from Jatropha curcas L. The half sib progenies were cultivated at Biojan farm, in Janaúba, MG. Plant height, stem diameter, number of branches and crown projection were assessed in all plants at three and six months old.
Juhász, Ana Cristina Pinto, Morais, Danielle de Lourdes Batista, Soares, Bruno Oliveira, Pimenta, Samy, Rabello, Hudson de Oliveira, Resende, Marcos Deon Vilela de   +5 more
openaire   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The effect of phenotyping, adult selection, and mating strategies on genetic gain and rate of inbreeding in black soldier fly breeding programs. [PDF]

Genet Sel Evol
Slagboom M, Nielsen HM, Kargo M, Henryon M, Hansen LS.   +4 more
europepmc   +1 more source

OPTIMAL-TUNING OF PID CONTROLLER GAINS USING GENETIC ALGORITHMS [PDF]

, 2011
Ömer Gündoğdu
openalex  

Optimal Gain Tuning for Contour Control of NC Machine Tools by Using Genetic Algorithm.

, 2001
Hidekazu Miyagawa, Akihiro Yamamoto, Shigeru Futami, Tadashi Sumimoto, Satoru Goto, Masatoshi Nakamura   +5 more
openalex   +2 more sources

Genetic Gains to Grain Yield of Maize Varieties for Small Farmers in Brazil

, 2020
Ana Paula Cândido Gabriel Berilli, Rafael Nunes de Almeida, Luis Eduardo Gottardo, Monique Moreira Moulin, Messias Gonzaga Pereira, Sávio da Silva Berilli, Júlio Cesar Fiorio Vettorazzi, R. dos S. Trindade, Robson Ferreira de Almeida   +8 more
openalex   +2 more sources