Results 281 to 290 of about 1,195,293 (349)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

The impact of genomic selection on genetic diversity and genetic gain in three French dairy cattle breeds. [PDF]

Genet Sel Evol, 2019
Doublet AC, Croiseau P, Fritz S, Michenet A, Hozé C, Danchin-Burge C, Laloë D, Restoux G.   +7 more
europepmc   +1 more source

The Potential of Aspen Clonal Forestry in Alberta: Breeding Regions and Estimates of Genetic Gain from Selection

, 2012
Tim Gylander, Andreas Hamann, Jean Sébastien Brouard, Barb R. Thomas   +3 more
openalex   +2 more sources

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Improving Short- and Long-Term Genetic Gain by Accounting for Within-Family Variance in Optimal Cross-Selection. [PDF]

Front Genet, 2019
Allier A, Lehermeier C, Charcosset A, Moreau L, Teyssèdre S.   +4 more
europepmc   +1 more source

GENETIC IMPROVEMENT OF WEANING WEIGHT, YEARLING WEIGHT, BODY WEIGHT GAIN AND BODY DIMENSION OF BALI CATTLE

, 2012
Andoyo Supriyantono, Lukman Hakim, Suyadi Suyadi, I. Ismudiono   +3 more
openalex   +2 more sources

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Enhancing the rate of genetic gain in public-sector plant breeding programs: lessons from the breeder's equation. [PDF]

Theor Appl Genet, 2019
Cobb JN, Juma RU, Biswas PS, Arbelaez JD, Rutkoski J, Atlin G, Hagen T, Quinn M, Ng EH.   +8 more
europepmc   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Pedigree relationships to control inbreeding in optimum-contribution selection realise more genetic gain than genomic relationships. [PDF]

Genet Sel Evol, 2019
Henryon M, Liu H, Berg P, Su G, Nielsen HM, Gebregiwergis GT, Sørensen AC.   +6 more
europepmc   +1 more source