Results 141 to 150 of about 483,969 (264)

Deep genome sequencing reveals extensive genetic heterogeneity in early human placentas. [PDF]

Nat Commun
Miceikaite I, Fagerberg C, Brasch-Andersen C, Torring PM, Schlott Kristiansen B, Hao Q, Sperling L, Larsen MJ.   +7 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition. [PDF]

Front Genet
Onder G, Ozdemir O, Taylan F, Canpolat C, Yalcin K, Erbey F, Sozmen BO, Asarcikli F, Bayhan T, Akcabelen YM, Yarali N, Ozbek NY, Bozkaya IO, Kacar D, Ergun B, Akkus A, Albayrak D, Ince E, Demirsoy U, Ozdemir GN, Dogru O, Aras S, Aydin E, Unal B, Amanvermez U, Dogan OA, Akyoney S, Sayitoglu M, Nordgren A, Bugra Agaoglu N, Ozbek U, Ng OH.   +31 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The Causal Pivot: A structural approach to genetic heterogeneity and variant discovery in complex diseases. [PDF]

Am J Hum Genet
Shaw CA, Williams CJ, Tan T, Illera D, Di N, Shulman JM, Belmont JW.   +6 more
europepmc   +1 more source

Genetic Heterogeneity in Breast Cancer [PDF]

JNCI Journal of the National Cancer Institute, 1992
S R, Wolman, G H, Heppner
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Divergent Clonal Evolution and Early Dissemination Promote Genetic Heterogeneity of Metastases in Castration-Resistant Prostate Cancer. [PDF]

Cancer Res
Hosseini N, Mannan R, Rebernick RJ, Su F, Wang R, Cao X, Lako A, Mellacheruvu D, Hu J, Alumkal JJ, Reichert ZR, Malik R, Mehra R, Chinnaiyan AM, Cieslik MP.   +14 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Morphological and Genetic Heterogeneity in <i>Aedes aegypti</i> (Diptera: Culicidae) Populations Across Diverse Landscapes in West Africa. [PDF]

Ecol Evol
Agboli E, Zahouli JZB, Sauer FG, Sombie A, Biré YN, Adjobi CN, Cadar D, Horváth B, Tomazatos A, Schmidt-Chanasit J, Lühken R, Tóth GE, Badolo A, Jöst H.   +13 more
europepmc   +1 more source