Results 61 to 70 of about 4,320,960 (307)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Molecular Characterization of Syndromic Hearing Loss in North African Moroccan Families

Biomolecules
Hearing loss (HL) is a common sensory disorder, with syndromic forms accounting for ~30% of genetic cases. Due to phenotypic and genetic heterogeneity, accurate diagnosis remains challenging.
Khawla El Fizazi, Amama Ghaffar, Laila Bouguenouch, Irum Badshah Saleem, Karim Ouldim, Zubair M. Ahmed, Mohammed Ridal, Saima Riazuddin   +7 more
doaj   +1 more source

Determination of ERG(+), EZH2, NKX3.1, and SPINK‐1 subtypes to evaluate their association with clonal origin and disease progression in multifocal prostate cancer

Cancer Reports, 2023
Background The prognostic relevance of prostate cancer (PCa) molecular subtypes remains controversial, given the presence of multiple foci with the possibility of different subtypes in the same patient. Aim To determine the clonal origin of heterogeneity
Yenifer Yamile Segura‐Moreno, María Carolina Sanabria‐Salas, Jorge Andrés Mesa‐López De Mesa, Rodolfo Varela‐Ramirez, Natalia Lizeth Acosta‐Vega, Martha Lucía Serrano   +5 more
doaj   +1 more source

Genetic heterogeneity in self-reported depressive symptoms identified through genetic analyses of the PHQ-9

Psychological Medicine, 2019
Background Depression is a clinically heterogeneous disorder. Previous large-scale genetic studies of depression have explored genetic risk factors of depression case–control status or aggregated sums of depressive symptoms, ignoring possible clinical or
Jackson G. Thorp, A. Marees, Jue-Sheng Ong, Jiyuan An, S. Macgregor, E. Derks   +5 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Journal of Pathology, 2019
Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer; however, little is known about genetic heterogeneity in these lesions. The objective of this study was to characterize genetic heterogeneity in IPMNs at the single‐cell
Y. Kuboki, Catherine G. Fischer, Violeta Beleva Guthrie, Wenjie Huang, Jun Yu, Peter Chianchiano, W. Hosoda, Hao Zhang, Lily Zheng, X. Shao, E. Thompson, Kevin M. Waters, J. Poling, Jin He, M. Weiss, elliot k fishman, M. Goggins, R. Hruban, Nicholas J. Roberts, R. Karchin, L. Wood   +20 more
semanticscholar   +1 more source

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Cell, 2020
Summary Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an important clinical challenge. However, the extent, origin, and drivers of ITH across cancer types are poorly understood.
S. Dentro, I. Leshchiner, K. Haase, M. Tarabichi, J. Wintersinger, A. Deshwar, K. Yu, Yulia Rubanova, G. Macintyre, J. Demeulemeester, I. Vázquez-García, K. Kleinheinz, D. Livitz, S. Malikić, Nilgun Donmez, Subhajit Sengupta, Pavana Anur, Clemency Jolly, Marek Cmero, Daniel Rosebrock, S. Schumacher, Yu Fan, M. Fittall, Ruben M. Drews, Xiaotong Yao, T. Watkins, Juhee Lee, M. Schlesner, Hongtu Zhu, D. Adams, N. Mcgranahan, C. Swanton, G. Getz, P. Boutros, M. Imieliński, R. Beroukhim, S. C. Sahinalp, Yuan Ji, M. Peifer, I. Martincorena, Florian Markowetz, Ville Mustonen, Ke Yuan, M. Gerstung, P. Spellman, Wenyi Wang, Q. Morris, D. Wedge, P. van Loo, Stefan C. Ignaty Moritz Clemency Kerstin Maxime Jeff Amit Dentro Leshchiner Gerstung Jolly Haase Tarabichi W, S. Dentro, I. Leshchiner, M. Gerstung, Clemency Jolly, K. Haase, M. Tarabichi, J. Wintersinger, A. Deshwar, K. Yu, Santiago Gonzalez, Yulia Rubanova, G. Macintyre, J. Demeulemeester, D. Adams, Pavana Anur, R. Beroukhim, Paul C. Boutros, D. Bowtell, P. Campbell, S. Cao, E. Christie, Marek Cmero, Yupeng Cun, K. Dawson, Nilgun Donmez, Ruben M. Drews, R. Eils, Yu Fan, M. Fittall, D. Garsed, G. Getz, G. Ha, M. Imieliński, L. Jerman, Yuan Ji, K. Kleinheinz, Juhee Lee, H. Lee-Six, D. Livitz, S. Malikić, Florian Markowetz, I. Martincorena, T. Mitchell, V. Mustonen, Layla Oesper, M. Peifer, Myron Peto, Benjamin J. Raphael, Daniel Rosebrock, S. C. Sahinalp, A. Salcedo, M. Schlesner, S. Schumacher, Subhajit Sengupta, Ruian Shi, S. Shin, Lincoln D. Stein, O. Spiro, I. Vázquez-García, Shankar Vembu, D. Wheeler, Tsun-Po Yang, Xiaotong Yao, Ke Yuan, Hongtu Zhu, Wenyi Wang, Q. Morris, P. Spellman, D. Wedge, P. van Loo   +119 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dementia-related genetic variants in an Italian population of early-onset Alzheimer’s disease

Frontiers in Aging Neuroscience, 2022
Early-onset Alzheimer’s disease (EOAD) is the most common form of early-onset dementia. Although three major genes have been identified as causative, the genetic contribution to the disease remains unsolved in many patients.
Anna Bartoletti-Stella, Martina Tarozzi, Giacomo Mengozzi, Francesca Asirelli, Laura Brancaleoni, Laura Brancaleoni, Nicola Mometto, Michelangelo Stanzani-Maserati, Simone Baiardi, Simone Baiardi, Simona Linarello, Marco Spallazzi, Roberta Pantieri, Elisa Ferriani, Paolo Caffarra, Rocco Liguori, Rocco Liguori, Piero Parchi, Piero Parchi, Sabina Capellari, Sabina Capellari   +20 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source