Results 51 to 60 of about 3,275,705 (300)

Genetic response to environmental heterogeneity

Nature, 1974
Uploaded by Plazi for TaxoDros. We do not have abstracts.
J F, McDonald, F J, Ayala
openaire   +3 more sources

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Genetic heterogeneity of residual variance - estimation of variance components using double hierarchical generalized linear models [PDF]

, 2010
Background The sensitivity to microenvironmental changes varies among animals and may be under genetic control. It is essential to take this element into account when aiming at breeding robust farm animals.
Erling Strandberg, Rönnegård, Lars, Mulder, Herman A., Felleki Majbritt, Fikse, Freddy, Rönnegård Lars, Majbritt Felleki, Ronnegard, L., Fikse Freddy, Felleki, M., Lars Rönnegård, Freddy Fikse, Herman A Mulder, Strandberg Erling, Mulder, H.A., Strandberg, Erling, Fikse, F., Felleki, Majbritt, Mulder Herman A, Strandberg, E., Rönnegård, Lars,, Felleki, Majbritt,, Strandberg, Erling,, Sveriges lantbruksuniversitet., Fikse, Freddy,   +24 more
core   +1 more source

Rare BLK, CEL, KLF11, PDX1, and PAX4 Gene Variants in Russian Patients with Monogenic Diabetes: Clinical and Molecular Characterization

Biomedicines
Background: Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic diabetes forms that are frequently misclassified as type 1 or type 2 diabetes due to overlapping phenotypic features.
Rita I. Khusainova, Ildar R. Minniakhmetov, Dmitry N. Laptev, Mariya P. Koltakova, Roman V. Deev, Bulat I. Yalaev, Yaroslav V. Dvoryanchikov, Elena A. Sechko, Natalia G. Mokrysheva   +8 more
doaj   +1 more source

Monitoring and Management of Bardet-Biedl Syndrome: What the Multi-Disciplinary Team Can Do

Journal of Multidisciplinary Healthcare, 2022
Lavinia Caba,1,* Laura Florea,2,* Elena Emanuela Braha,3,* Valeriu Vasile Lupu,4,* Eusebiu Vlad Gorduza1,* 1Department of Mother and Child Medicine – Medical Genetics, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi,
Caba L, Florea L, Braha EE, Lupu VV, Gorduza EV   +4 more
doaj  

The Molecular Characterization of Genetic Abnormalities in Esophageal Squamous Cell Carcinoma May Foster the Development of Targeted Therapies

Current Oncology, 2023
Esophageal cancer is among the most common tumors in the world and is associated with poor outcomes, with a 5-year survival rate of about 10–20%. Two main histological subtypes are observed: esophageal squamous cell carcinoma (ESCC), more frequent among ...
Ugo Testa, Germana Castelli, Elvira Pelosi   +2 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

: Genetic heterogeneity of bipolar disorder [PDF]

, 2010
International audienceBipolar disorder has a genetic component, but the mode of inheritance remains unclear. A previous genome scan conducted in 70 European families led to detect eight regions linked to bipolar disease. Here, we present an investigation
Ohlraun, Stephanie, Roche, Siobhan, Malafosse, Alain, Blackwood, D., Mckeon, Patrick, Mojca C. Dernovsek, Abou Jamra, Rami, Gurling, Hugh, Nöthen, Markus,, Henry, Chantal, Schulze, T.G., Malafosse, A., Albus, Margot, Schulze, Thomas, G., Mathieu, F., Propping, Peter, Gurling, H., Ferrero, François, Etain, B., Lathrop, Mark, Leboyer, Marion, Bellivier, F., Lathrop, M., Hugh Gurling, Martin Preisig, Andrej Marusic, Walter J. Muir, Cichon, S., Maier, Wolfgang, Patrick McKeon, Leboyer, M., Nöthen, Markus, M., Zelenica, Diana, Albus, M., Rami Abou Jamra, Muir, Walter J., Wolfgang Maier, Dernovsek, Mojca C., Noethen, Markus, Sven Cichon, Céline Charon, Preisig, Martin, Frank Bellivier, Dernovsek, Mojca,, Marie-Hélène Dizier, Stéphane Jamain, Dizier, M.H., Blackwood, Douglas, Charon, C., Schulze, Thomas G., Peter Propping, Stephanie Ohlraun, McKeon, P., Zelenica, D., Dernovsek, M.C., Bellivier, Frank, Muir, Walter, J., Schulze, Thomas,, François Ferrero, Marion Leboyer, Preisig, M., Jamain, Stéphane, Nothen, Markus, Dernovsek, Mojca, Z., Markus Nöthen, Jamain, S., Mathieu, Flavie, Etain, Bruno, Marcella Rietschel, Rietschel, M., Charon, Céline, Johannes Schumacher, Maier, W., Mark Lathrop, Flavie Mathieu, Propping, P., Siobhan Roche, Alain Malafosse, Nöthen, M., Marusic, A., Muir, Walter,, Rietschel, Marcella, Ohlraun, S., Bruno Etain, Roche, S., Douglas Blackwood, Diana Zelenica, Cichon, Sven, Chantal Henry, Margot Albus, Schumacher, Johannes, Marusic, Andrej, Ferrero, F., Thomas G. Schulze, Schumacher, J., Abou Jamra, R., Dizier, Marie-Hélène, Henry, C., Muir, W.J.   +98 more
core   +1 more source

Molecular Characterization of Syndromic Hearing Loss in North African Moroccan Families

Biomolecules
Hearing loss (HL) is a common sensory disorder, with syndromic forms accounting for ~30% of genetic cases. Due to phenotypic and genetic heterogeneity, accurate diagnosis remains challenging.
Khawla El Fizazi, Amama Ghaffar, Laila Bouguenouch, Irum Badshah Saleem, Karim Ouldim, Zubair M. Ahmed, Mohammed Ridal, Saima Riazuddin   +7 more
doaj   +1 more source

Determination of ERG(+), EZH2, NKX3.1, and SPINK‐1 subtypes to evaluate their association with clonal origin and disease progression in multifocal prostate cancer

Cancer Reports, 2023
Background The prognostic relevance of prostate cancer (PCa) molecular subtypes remains controversial, given the presence of multiple foci with the possibility of different subtypes in the same patient. Aim To determine the clonal origin of heterogeneity
Yenifer Yamile Segura‐Moreno, María Carolina Sanabria‐Salas, Jorge Andrés Mesa‐López De Mesa, Rodolfo Varela‐Ramirez, Natalia Lizeth Acosta‐Vega, Martha Lucía Serrano   +5 more
doaj   +1 more source