Results 31 to 40 of about 4,320,960 (307)
Rejection of immunogenic tumor clones is limited by clonal fraction
eLife, 2018 Tumors often co-exist with T cells that recognize somatically mutated peptides presented by cancer cells on major histocompatibility complex I (MHC-I). However, it is unknown why the immune system fails to eliminate immune-recognizable neoplasms before ...
Ron S Gejman +6 more
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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
NatureType 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4.
Ken Suzuki +362 more
semanticscholar +1 more source
Annals of Indian Academy of NeurologyBackground and Objectives: Hereditary spastic paraplegia (HSP) is a group of neurodegenerative disorders characterized by genetic and clinical diversity.
Taha Reşid Özdemir +7 more
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Recurrent Glioma With Lineage Conversion From Oligodendroglioma to Astrocytoma in Two Cases
Frontiers in Oncology, 2019 Following the introduction of the molecular classification of gliomas by the WHO in 2016, molecularly-proven lineage conversion during glioma recurrence has never been reported. The reported two cases were initially diagnosed as oligodendroglioma with 1p/
Jo-Heon Kim +9 more
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Implications of genetic heterogeneity in cancer [PDF]
Annals of the New York Academy of Sciences, 2012 DNA sequencing studies have established that many cancers contain tens of thousands of clonal mutations throughout their genomes, which is difficult to reconcile with the very low rate of mutation in normal human cells. This observation provides strong evidence for the mutator phenotype hypothesis, which proposes that a genome‐wide elevation in the ...
Michael W, Schmitt +2 more
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Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities
Frontiers in Immunology, 2021 Acute myeloid leukemia (AML) is one of the most common types of leukemia in adults. While complete remission can be obtained with intensive chemotherapy in young and fit patients, relapse is frequent and prognosis remains poor. Leukemic cells are thought
Tony Marchand +3 more
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Item-level analyses reveal genetic heterogeneity in neuroticism
Nature Communications, 2018 Genome-wide association studies (GWAS) of psychological traits are generally conducted on (dichotomized) sums of items or symptoms (e.g., case-control status), and not on the individual items or symptoms themselves.
M. Nagel +4 more
semanticscholar +1 more source
Pituitary stalk interruption syndrome is characterized by genetic heterogeneity
PLoS ONE, 2020 Pituitary stalk interruption syndrome is a rare disorder characterized by an absent or ectopic posterior pituitary, interrupted pituitary stalk and anterior pituitary hypoplasia, as well as in some cases, a range of heterogeneous somatic anomalies.
R. Brauner +3 more
semanticscholar +1 more source
Scheimpflug imaging for keratoconus and ectatic disease
Indian Journal of Ophthalmology, 2013 Scheimpflug cross-sectioning anterior segment imaging offers significant advantages over traditional placido based curvature analysis and ultrasound pachymetry. The accurate measurement of both the anterior and posterior corneal surfaces and the anterior
Michael W Belin, Renato Ambrósio
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Genetic Heterogeneity in Human Disease [PDF]
Cell, 2010 Strong evidence suggests that rare mutations of severe effect are responsible for a substantial portion of complex human disease. Evolutionary forces generate vast genetic heterogeneity in human illness by introducing many new variants in each generation.
McClellan, Jon, King, Mary-Claire
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