Results 31 to 40 of about 3,275,705 (300)

Rejection of immunogenic tumor clones is limited by clonal fraction

eLife, 2018
Tumors often co-exist with T cells that recognize somatically mutated peptides presented by cancer cells on major histocompatibility complex I (MHC-I). However, it is unknown why the immune system fails to eliminate immune-recognizable neoplasms before ...
Ron S Gejman, Aaron Y Chang, Heather F Jones, Krysta DiKun, Abraham Ari Hakimi, Andrea Schietinger, David A Scheinberg   +6 more
doaj   +1 more source

Genetic Evaluation of Patients with Clinically Suspected Hereditary Spastic Paraplegia with Seven Novel Variants

Annals of Indian Academy of Neurology
Background and Objectives: Hereditary spastic paraplegia (HSP) is a group of neurodegenerative disorders characterized by genetic and clinical diversity.
Taha Reşid Özdemir, Pınar Gençpınar, Roza Sarıteke, Safa M Dagdas, Senay Haspolat, Bedile I Tiftikcioglu, Nihal Olgaç Dündar, Berk Özyılmaz   +7 more
doaj   +1 more source

Recurrent Glioma With Lineage Conversion From Oligodendroglioma to Astrocytoma in Two Cases

Frontiers in Oncology, 2019
Following the introduction of the molecular classification of gliomas by the WHO in 2016, molecularly-proven lineage conversion during glioma recurrence has never been reported. The reported two cases were initially diagnosed as oligodendroglioma with 1p/
Jo-Heon Kim, Woo-Youl Jang, Tae-Young Jung, Shin Jung, Kyung-Keun Kim, Hyung-Seok Kim, Eun-Hee Kim, Min-Cheol Lee, Kyung-Sub Moon, Kyung-Hwa Lee   +9 more
doaj   +1 more source

Genetic Heterogeneity in Human Disease [PDF]

Cell, 2010
Strong evidence suggests that rare mutations of severe effect are responsible for a substantial portion of complex human disease. Evolutionary forces generate vast genetic heterogeneity in human illness by introducing many new variants in each generation.
McClellan, Jon, King, Mary-Claire
openaire   +2 more sources

Genetic origins, singularity, and heterogeneity of Basques

, 2021
International audienceGenetic origins, singularity, and heterogeneity of Basques Highlights d Clear genetic singularity of Basques is observed at wide-and fine-scale levels d Basque differentiation might lie on the absence of gene flow after the Iron ...
Salaberria, Jasone, Bauduer, Frédéric, Bertranpetit, Jaume, 1952-, Flores Bello, André, 1992-, Calafell, Francesc, Quintana-Murci, Lluis, Calafell i Majó, Francesc, Bertranpetit, Jaume, Flores-Bello, André, Quintana Murci, Lluis, Comas, David, 1969-, Comas, David, Oyharçabal, Bernard, Beñat, B., Oyharçabal, Bernard   +13 more
core   +1 more source

Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities

Frontiers in Immunology, 2021
Acute myeloid leukemia (AML) is one of the most common types of leukemia in adults. While complete remission can be obtained with intensive chemotherapy in young and fit patients, relapse is frequent and prognosis remains poor. Leukemic cells are thought
Tony Marchand, Tony Marchand, Tony Marchand, Sandra Pinho   +3 more
doaj   +1 more source

Genetic Heterogeneity and Human Disease

, 2015
Overview of genetic heterogeneity in rare ...
Alessandra Ferlini, Sergio Fini
core   +1 more source

Scheimpflug imaging for keratoconus and ectatic disease

Indian Journal of Ophthalmology, 2013
Scheimpflug cross-sectioning anterior segment imaging offers significant advantages over traditional placido based curvature analysis and ultrasound pachymetry. The accurate measurement of both the anterior and posterior corneal surfaces and the anterior
Michael W Belin, Renato Ambrósio
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Common in atherogenesis and carcinogenesis: clonal hematopoiesis

Российский кардиологический журнал, 2023
Clonal hematopoiesis is a common age-dependent state accompanied by the expansion of mutant hematopoietic stem cells as a result of somatic mutations and is associated with a high risk of hematopoietic neoplasms and cardiovascular diseases.
A. A. Sleptsov, M. S. Nazarenko, V. Р. Puzyrev   +2 more
doaj   +1 more source