Results 21 to 30 of about 4,320,960 (307)

Triple negative breast cancer (TNBC): non-genetic tumor heterogeneity and immune microenvironment: emerging treatment options

Pharmacology and Therapeutics, 2022
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intra-tumoral heterogeneity, and frequently develops resistance to therapies. Tumor heterogeneity and lack of biomarkers are thought to be some of the most difficult
J. So, J. Ohm, S. Lipkowitz, Li Yang
semanticscholar   +1 more source

Interleukin-8 heterozygous polymorphism (-251 T/A and +781 C/T) increases the risk of Helicobacter pylori-infection gastritis in children: a case control study [PDF]

Medicinski Glasnik, 2020
Aim To investigate the effects of interleukin-8 (IL-8) -251 T/A and +781 C/T polymorphism on the risk of Helicobacter pylori-infection gastritis in children, and the IL-8 level of children with or without gastritis H.
Supriatmo, Gontar Alamsyah Siregar, Iqbal Pahlevi Adeputra Nasution, Oke Rina Ramayani   +3 more
doaj   +1 more source

Sorafenib Resistance in Hepatocellular Carcinoma: The Relevance of Genetic Heterogeneity

Cancers, 2020
Despite advances in biomedicine, the incidence and the mortality of hepatocellular carcinoma (HCC) remain high. The majority of HCC cases are diagnosed in later stages leading to the less than optimal outcome of the treatments. Molecular targeted therapy
L. K. Cabral, C. Tiribelli, Caecilia Sukowati   +2 more
semanticscholar   +1 more source

Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing

eLife, 2020
Copy number alterations (CNAs) play an important role in molding the genomes of breast cancers and have been shown to be clinically useful for prognostic and therapeutic purposes.
T. Baslan, J. Kendall, Konstantin Volyanskyy, K. McNamara, H. Cox, Sean D'Italia, F. Ambrosio, M. Riggs, L. Rodgers, A. Leotta, Junyan Song, Yong Mao, Jie Wu, Ronak H. Shah, Rodrigo Gularte-Mérida, Kalyani Chadalavada, G. Nanjangud, V. Varadan, Assaf Gordon, C. Curtis, A. Krasnitz, N. Dimitrova, L. Harris, M. Wigler, J. Hicks   +24 more
semanticscholar   +1 more source

Topography-guided custom ablation treatment for treatment of keratoconus

Indian Journal of Ophthalmology, 2013
Keratoconus is a progressive ectatic disorder of the cornea which often presents with fluctuating refraction and high irregular astigmatism. Correcting the vision of these patients is often a challenge because glasses are unable to correct the irregular ...
Rohit Shetty, Sharon D′Souza, Samaresh Srivastava, R Ashwini   +3 more
doaj   +1 more source

Extrachromosomal oncogene amplification drives tumor evolution and genetic heterogeneity

Nature, 2017
Human cells have twenty-three pairs of chromosomes. In cancer, however, genes can be amplified in chromosomes or in circular extrachromosomal DNA (ecDNA), although the frequency and functional importance of ecDNA are not understood.
Kristen M. Turner, Viraj Deshpande, Doruk Beyter, Tomoyuki Koga, Jessica M. Rusert, Catherine Lee, Bin Li, K. Arden, B. Ren, D. Nathanson, H. Kornblum, H. Kornblum, Michael D. Taylor, S. Kaushal, W. Cavenee, R. Wechsler-Reya, F. Furnari, S. Vandenberg, P. Rao, G. Wahl, V. Bafna, P. Mischel   +21 more
semanticscholar   +1 more source

Genetic Heterogeneity in Familial Hyperinsulinism [PDF]

Human Molecular Genetics, 1998
Familial hyperinsulinism (HI) is a disorder characterized by dysregulation of insulin secretion and profound hypoglycemia. Mutations in both the Kir6.2 and sulfonylurea receptor (SUR1) genes have been associated with the autosomal recessive form of this disorder.
A, Nestorowicz, B, Glaser, B A, Wilson, S L, Shyng, C G, Nichols, C A, Stanley, P S, Thornton, M A, Permutt   +7 more
openaire   +2 more sources

Bovine nebovirus infection (review)

Ветеринария сегодня, 2023
Animal husbandry is one of the main agricultural industries in most countries over the world as well as in the Russian Federation, and its profitability is determined by three main factors: the animal genetic potential, complete diet and freedom from ...
V. A. Mischenko, A. V. Mischenko, T. B. Nikeshina, Yu. V. Brovko, A. I. Kushlubaeva   +4 more
doaj   +1 more source

The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells

bioRxiv, 2019
The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity.
Zhiyuan Hu, Mara Artibani, Abdulkhaliq Alsaadi, N. Wietek, M. Morotti, Laura Santana Gonzalez, Salma El-Sahhar, Mohammad Karaminejadranjbar, Garry Mallett, Tingyan Shi, K. Masuda, Yiyan Zheng, K. Chong, S. Damato, S. Dhar, R. Campanile, H. S. Majd, V. Cerundolo, T. Sauka-Spengler, C. Yau, A. Ahmed   +20 more
semanticscholar   +1 more source

Genetic correlates of phenotypic heterogeneity in autism

Nature Genetics, 2022
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated genetic differences between autistic individuals (nmax = 12,893) based on core and associated features of ...
V. Warrier, Xinhe Zhang, Patrick J. Reed, A. Havdahl, T. Moore, F. Cliquet, C. Leblond, T. Rolland, A. Rosengren, Antonia San Jose Hannah Daisy Jessica Jessica Claire Betha Caceres Hayward Crawley Faulkner Sabet Ellis Oakle, A. S. J. Cáceres, H. Hayward, D. Crawley, J. Faulkner, Jessica Sabet, C. Ellis, B. Oakley, E. Loth, T. Charman, D. Murphy, R. Holt, Jack Waldman, J. Upadhyay, Nicola Gunby, M. Lai, Gwilym Renouf, A. Ruigrok, Emily Taylor, H. Ziauddeen, J. Deakin, Sara Ambrosino di Bruttopilo, Sarai van Dijk, Yvonne Rijks, Tabitha Koops, M. Douma, A. Spaan, I. Selten, Maarten Steffers, Anna Ver Loren van Themaat, Nico Bast, S. Baumeister, Larry O’Dwyer, Carsten Bours, A. Rausch, D. von Rhein, I. Cornelissen, Yvette de Bruin, Maartje J Graauwmans, E. Kostrzewa, É. Cauvet, K. Tammimies, Rouslan Sitnikow, G. Dumas, Yang-Min Kim, T. Bourgeron, David M. Jonas Thomas Preben Bo Ole Merete Hougaard Bybjerg-Grauholm Werge Mortensen Mors Nor, D. Hougaard, J. Bybjerg-Grauholm, T. Werge, P. Mortensen, O. Mors, M. Nordentoft, Dwaipayan Armandina Carrie Isabelle Tracey Paula Alex Graham Adhya Alamanza Allison Garvey Parsons Smith Tsompa, Dwaipayan Adhya, Armandina Alamanza, C. Allison, Isabelle Garvey, Tracy Parsons, Paula Smith, A. Tsompanidis, G. Burton, A. Heazell, L. Gabis, T. Biron-Shental, Madeline A. Lancaster, D. Srivastava, J. Mill, D. Rowitch, M. Hurles, D. Geschwind, A. Børglum, E. Robinson, J. Grove, H. Martin, S. Baron-Cohen   +84 more
semanticscholar   +1 more source