Results 21 to 30 of about 945,528 (300)
Clinical implications of the molecular biology of prostate cancer: Review article
Revista de la Facultad de Medicina Humana, 2022 To understand the term genomic heterogeneity in prostate cancer, we must understand the clonal genomic evolution of cancer, as well as knowing that it is a dynamic and evolutionary phenomenon.
María del Carmen Castro-Mujica
doaj +1 more source
Implications of genetic heterogeneity in cancer [PDF]
Annals of the New York Academy of Sciences, 2012 DNA sequencing studies have established that many cancers contain tens of thousands of clonal mutations throughout their genomes, which is difficult to reconcile with the very low rate of mutation in normal human cells. This observation provides strong evidence for the mutator phenotype hypothesis, which proposes that a genome‐wide elevation in the ...
Michael W, Schmitt +2 more
openaire +2 more sources
Topography-guided custom ablation treatment for treatment of keratoconus
Indian Journal of Ophthalmology, 2013 Keratoconus is a progressive ectatic disorder of the cornea which often presents with fluctuating refraction and high irregular astigmatism. Correcting the vision of these patients is often a challenge because glasses are unable to correct the irregular ...
Rohit Shetty +3 more
doaj +1 more source
Further genetic heterogeneity for autosomal dominant human sutural cataracts [PDF]
, 2003 A unique sutural cataract was observed in a 4-generation German family to be transmitted as an isolated autosomal, dominant trait. Since mutations in the gamma-crystallin encoding CRYG genes have previously been demonstrated to be the most frequent ...
Billingsley, G. +6 more
core +1 more source
Bovine nebovirus infection (review)
Ветеринария сегодня, 2023 Animal husbandry is one of the main agricultural industries in most countries over the world as well as in the Russian Federation, and its profitability is determined by three main factors: the animal genetic potential, complete diet and freedom from ...
V. A. Mischenko +4 more
doaj +1 more source
Assessment of the dynamics of microparasite infections in genetically homogeneous and heterogeneous populations using a stochastic epidemic model [PDF]
, 2008 The aim of this paper was to explore the effect of genetic heterogeneity in host resistance to infection on the population-level risks and outcomes of epidemics.
Bishop, S. C. +2 more
core +1 more source
Rejection of immunogenic tumor clones is limited by clonal fraction
eLife, 2018 Tumors often co-exist with T cells that recognize somatically mutated peptides presented by cancer cells on major histocompatibility complex I (MHC-I). However, it is unknown why the immune system fails to eliminate immune-recognizable neoplasms before ...
Ron S Gejman +6 more
doaj +1 more source
Recurrent Glioma With Lineage Conversion From Oligodendroglioma to Astrocytoma in Two Cases
Frontiers in Oncology, 2019 Following the introduction of the molecular classification of gliomas by the WHO in 2016, molecularly-proven lineage conversion during glioma recurrence has never been reported. The reported two cases were initially diagnosed as oligodendroglioma with 1p/
Jo-Heon Kim +9 more
doaj +1 more source
Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities
Frontiers in Immunology, 2021 Acute myeloid leukemia (AML) is one of the most common types of leukemia in adults. While complete remission can be obtained with intensive chemotherapy in young and fit patients, relapse is frequent and prognosis remains poor. Leukemic cells are thought
Tony Marchand +3 more
doaj +1 more source
Non-genetic heterogeneity criticality and cell differentiation
, 2014 The different cell types in a living organism acquire their identity through the process of cell differentiation in which the multipotent progenitor cells differentiate into distinct cell types.
Bose, Indrani +2 more
core +1 more source