Results 1 to 10 of about 945,379 (154)

Soybean locus qDTF-7 as an example of genetic heterogeneity associated with flowering and maturity time [PDF]

Вавиловский журнал генетики и селекции
Genome-wide association studies (GWAS) have become a standard approach for identifying quantitative trait loci associated with diverse phenotypic traits. Further investigation of the locus – specifically, the search for the causal gene and mutation – may
R. N. Perfil’ev, M. I. Shmatova, A. B. Shcherban, E. A. Salina   +3 more
doaj   +2 more sources

Reduced Genetic Heterogeneity for Stable Bioproduction by Harnessing the Bias and Mechanism of Mutation [PDF]

Microbial Biotechnology
Microbial bioproduction is an important approach to realising green biomanufacturing. However, poor bioproduction stability caused by genetic heterogeneity is one of the important factors limiting its industrial‐scale applications. Here, two methods have
Yanting Cao, Yaokang Wu, Xueqin Lv, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu   +7 more
doaj   +2 more sources

Acute Promyelocytic Leukemia (APL): A Review of the Classic and Emerging Target Therapies towards Molecular Heterogeneity

Future Pharmacology, 2023
The occurrence of severe bleeding syndrome because of the PML-RARα fusion protein is a life-threatening event in APL. This protein destabilizes homeostasis, maturation, remodeling, and tissue regeneration in addition to hampering the maintenance and ...
Tâmara Dauare de Almeida, Fernanda Cristina Gontijo Evangelista, Adriano de Paula Sabino   +2 more
doaj   +1 more source

Single-cell transcriptome analysis for cancer and biology of the pancreas: A review on recent progress

Frontiers in Genetics, 2023
Single-cell sequencing has become one of the most used techniques across the wide field of biology. It has enabled researchers to investigate the whole transcriptome at the cellular level across tissues, which unlocks numerous potentials for basic and ...
Mona Tamaddon, Mostafa Azimzadeh, Mostafa Azimzadeh, Mostafa Azimzadeh, Peyman Gifani, Peyman Gifani, Seyed Mohammad Tavangar, Seyed Mohammad Tavangar   +7 more
doaj   +1 more source

APOE alleles modulate associations of plasma metabolites with variants from multiple genes on chromosome 19q13.3

Frontiers in Aging Neuroscience, 2022
The APOE ε2, ε3, and ε4 alleles differentially impact various complex diseases and traits. We examined whether these alleles modulated associations of 94 single-nucleotide polymorphisms (SNPs) harbored by 26 genes in 19q13.3 region with 217 plasma ...
Alireza Nazarian, Elena Loiko, Hussein N. Yassine, Caleb E. Finch, Alexander M. Kulminski   +4 more
doaj   +1 more source

New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia

Journal of Lipid Research, 2009
This review summarizes the progress made in cutting through the biological and genetic complexity of the Gordian knot that is familial combined hyperlipidemia. We particularly focus on how the application of new genomic technologies, especially massively
Stuart D. Horswell, Helen E. Ringham, Carol C. Shoulders   +2 more
doaj   +1 more source

Two different homozygous mutations in two Turkish siblings: DGUOK and HPS5

Journal of Biochemical and Clinical Genetics, 2020
Background: Genetic disorders are enormously diverse both in terms of genotype and phenotype. Each case requires a careful and cautious investigation. Case Presentation: In this paper, we report two siblings who were admitted to our clinic with various ...
Muhsin Elmas, Umit Can Yildirim, Dilek Cavusoglu, Evrim Gurhan Tahta, Ebru Elmas, Tolga Altug Sen, Aysegul Bukulmez   +6 more
doaj   +1 more source

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer. [PDF]

, 2017
Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution.
Bivona, Trever G, Cai, Mei-Chun, Chen, Hong-Zhuan, Chen, Minjiang, Fu, Yujie, Gao, Wei-Qiang, Gu, Zhenyu, Jing, Ying, Ma, Pengfei, Shen, Ying, Wang, Mengzhao, Wu, Jie, Yan, Ying, Zhang, Shengzhe, Zhao, Xiaojing, Zhu, Liang, Zhuang, Guanglei   +16 more
core   +2 more sources

Interleukin-8 heterozygous polymorphism (-251 T/A and +781 C/T) increases the risk of Helicobacter pylori-infection gastritis in children: a case control study [PDF]

Medicinski Glasnik, 2020
Aim To investigate the effects of interleukin-8 (IL-8) -251 T/A and +781 C/T polymorphism on the risk of Helicobacter pylori-infection gastritis in children, and the IL-8 level of children with or without gastritis H.
Supriatmo, Gontar Alamsyah Siregar, Iqbal Pahlevi Adeputra Nasution, Oke Rina Ramayani   +3 more
doaj   +1 more source

Interleukin-10 gene polymorphism in patients with systemic lupus erythematosus and normal individuals of Kasakh population

Научно-практическая ревматология, 2003
An analysis of interleukin-10 (IL-10) gene polymorphism associative link with clinical variability in Kasakhs. 49 pts with systemic lupus erythematosus were included (48 female and I male).
Z E Omarbekova, R L Ivanova, I A Guseva, V A Myakotkin   +3 more
doaj   +1 more source