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Individual Genetic Heterogeneity

Genes, 2022
Genetic variation has been widely covered in literature, however, not from the perspective of an individual in any species. Here, a synthesis of genetic concepts and variations relevant for individual genetic constitution is provided. All the different levels of genetic information and variation are covered, ranging from whether an organism is unmixed ...
Mauno Vihinen, Vihinen Mauno
exaly   +3 more sources

Soybean locus qDTF-7 as an example of genetic heterogeneity associated with flowering and maturity time [PDF]

Вавиловский журнал генетики и селекции
Genome-wide association studies (GWAS) have become a standard approach for identifying quantitative trait loci associated with diverse phenotypic traits. Further investigation of the locus – specifically, the search for the causal gene and mutation – may
R. N. Perfil’ev, M. I. Shmatova, A. B. Shcherban, E. A. Salina   +3 more
doaj   +2 more sources

Reduced Genetic Heterogeneity for Stable Bioproduction by Harnessing the Bias and Mechanism of Mutation [PDF]

Microbial Biotechnology
Microbial bioproduction is an important approach to realising green biomanufacturing. However, poor bioproduction stability caused by genetic heterogeneity is one of the important factors limiting its industrial‐scale applications. Here, two methods have
Yanting Cao, Yaokang Wu, Xueqin Lv, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu   +7 more
doaj   +2 more sources

Genetic heterogeneity in cataracts

Indian Journal of Ophthalmology, 1978
Padma T, Murthy J, Reddy P
doaj   +2 more sources

Acute Promyelocytic Leukemia (APL): A Review of the Classic and Emerging Target Therapies towards Molecular Heterogeneity

Future Pharmacology, 2023
The occurrence of severe bleeding syndrome because of the PML-RARα fusion protein is a life-threatening event in APL. This protein destabilizes homeostasis, maturation, remodeling, and tissue regeneration in addition to hampering the maintenance and ...
Tâmara Dauare de Almeida, Fernanda Cristina Gontijo Evangelista, Adriano de Paula Sabino   +2 more
doaj   +1 more source

Heterogeneity in Genetic Conditions [PDF]

QJM: An International Journal of Medicine, 1992
The use of the term genetic heterogeneity in connection with type 2 neurofibromatosis in this edition [1] reflects the increasing clinical importance of precise genetic diagnosis. At its simplest genetic heterogeneity implies clinical similarity produced by different genes.
Evans, D., Harris, R.
openaire   +2 more sources

Genetic Heterogeneity of Cebocephaly [PDF]

Journal of Medical Genetics, 1974
Three infants with cebocephaly with entirely different aetiologies are described: one possibly representing the effect of a single mutant gene, one with apparent E trisomy, and one with D trisomy. In comparison with other reported patients, it is likely that infants with cebocephaly and no associated chromosomal abnormality have few, if any ...
L B, Holmes, S, Driscoll, L, Atkins
openaire   +2 more sources

Single-cell transcriptome analysis for cancer and biology of the pancreas: A review on recent progress

Frontiers in Genetics, 2023
Single-cell sequencing has become one of the most used techniques across the wide field of biology. It has enabled researchers to investigate the whole transcriptome at the cellular level across tissues, which unlocks numerous potentials for basic and ...
Mona Tamaddon, Mostafa Azimzadeh, Mostafa Azimzadeh, Mostafa Azimzadeh, Peyman Gifani, Peyman Gifani, Seyed Mohammad Tavangar, Seyed Mohammad Tavangar   +7 more
doaj   +1 more source

APOE alleles modulate associations of plasma metabolites with variants from multiple genes on chromosome 19q13.3

Frontiers in Aging Neuroscience, 2022
The APOE ε2, ε3, and ε4 alleles differentially impact various complex diseases and traits. We examined whether these alleles modulated associations of 94 single-nucleotide polymorphisms (SNPs) harbored by 26 genes in 19q13.3 region with 217 plasma ...
Alireza Nazarian, Elena Loiko, Hussein N. Yassine, Caleb E. Finch, Alexander M. Kulminski   +4 more
doaj   +1 more source

New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia

Journal of Lipid Research, 2009
This review summarizes the progress made in cutting through the biological and genetic complexity of the Gordian knot that is familial combined hyperlipidemia. We particularly focus on how the application of new genomic technologies, especially massively
Stuart D. Horswell, Helen E. Ringham, Carol C. Shoulders   +2 more
doaj   +1 more source