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Retroactive signaling in short signaling pathways. [PDF]
PLoS ONE, 2012 In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In
Jacques-Alexandre Sepulchre +2 more
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Wound healing and signaling pathways [PDF]
Open Life SciencesWound healing is a precisely regulated dynamic process in which signaling pathways play a central role. This article provides a comprehensive review of the signaling pathways involved in wound healing, emphasizing their roles in inflammation, vascular ...
Liu Zhe, Fang Yudong
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Conserved immunomodulatory transcriptional networks underlie antipsychotic-induced weight gain
Translational Psychiatry, 2021 Although antipsychotics, such as olanzapine, are effective in the management of psychiatric conditions, some patients experience excessive antipsychotic-induced weight gain (AIWG).
Rizaldy C. Zapata +6 more
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Signaling Pathways Involved in Rheumatoid Arthritis: Targets for New Therapeutic Interventions
NUST Journal of Natural Sciences, 2021 Rheumatoid arthritis is categorized as a systematic autoimmune disease which causes chronic disabilities exclusively in bones that are aligned with synovium.
Abdul Haseeb Khan +8 more
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Changes of Signaling Pathways in Hypothalamic Neurons with Aging
Current Issues in Molecular Biology, 2023 The hypothalamus is an important regulator of autonomic and endocrine functions also involved in aging regulation. The aging process in the hypothalamus is accompanied by disturbed intracellular signaling including insulin/insulin-like growth factor-1 ...
Petr M. Masliukov
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Frontiers in Oncology, 2022 Granulocyte colony-stimulating factor receptor (GCSFR) is a critical regulator of granulopoiesis. Studies have shown significant upregulation of GCSFR in a variety of cancers and cell types and have recognized GCSFR as a cytokine receptor capable of ...
Sungjin David Park +5 more
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Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity [PDF]
, 2016 Organ formation is achieved through the complex interplay between signaling pathways and transcriptional cascades. The canonical Wnt signaling pathway plays multiple roles during embryonic development including patterning, proliferation and ...
Cano, David A. +7 more
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Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways
Cells, 2022 Over the past two decades, cancer stem cells (CSCs) have emerged as an immensely studied and experimental topic, however a wide range of questions concerning the topic still remain unanswered; in particular, the mechanisms underlying the regulation of ...
Kevina Sonawala +2 more
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Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]
, 2020 The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo +8 more
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Signaling Pathways Regulating Thermogenesis
Frontiers in Endocrinology, 2021 Obesity, an excess accumulation of white adipose tissue (WAT), has become a global epidemic and is associated with complex diseases, such as type 2 diabetes and cardiovascular diseases.
Chihiro Tabuchi, Hei Sook Sul
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