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Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway
Cells, 2019 Leptin is an important secretory protein that regulates the body’s intake and energy consumption, and the functions of the Hh signaling pathway related to white adipocyte browning are controversial. It has been reported that leptin plays a critical
Jie Wang +8 more
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Frontiers in Endocrinology, 2022 Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
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A review of signal pathway induced by virulent protein CagA of Helicobacter pylori
Frontiers in Cellular and Infection Microbiology, 2023 Gastric cancer (GC), a common and high-mortality disease, still occupies an important position in current cancer research, and Helicobacter pylori (H. pylori) infection as its important risk factor has been a hot and challenging research area.
Haiqiang Wang +5 more
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Biology, 2021 Long-term imbalance between fatigue and recovery may eventually lead to muscle weakness or even atrophy. We previously reported that excessive exercise induces pathological cardiac hypertrophy.
Chen-Chen Sun +7 more
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Frontiers in Genetics, 2022 Osteosarcoma (OS) is a common bone cancer in children and adolescents, and metastasis and recurrence are the major causes of poor treatment outcomes. A better understanding of the tumor microenvironment is required to develop an effective treatment for ...
Ning Xu +6 more
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Antioxidants, 2021 Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of ...
Gerasimos P. Sykiotis
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Immunity, Inflammation and Disease, 2023 Background Interleukin‐1β (IL‐1β) is a pro‐inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects.
Peixuan Wang +3 more
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Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway. [PDF]
PLoS ONE, 2015 Pathway analysis is a common approach to gain insight from biological experiments. Signaling-pathway impact analysis (SPIA) is one such method and combines both the classical enrichment analysis and the actual perturbation on a given pathway.
Xianbin Li +3 more
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Frontiers in Immunology, 2023 Parasitoid wasps control pests via a precise attack leading to the death of the pest. However, parasitoid larvae exhibit self-protection strategies against bracovirus-induced reactive oxygen species impairment.
Xing-Cheng Li +56 more
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Rice, 2018 Background Magnaporthe oryzae, the causal fungus of rice blast disease, negatively impacts global rice production. Wild rice (Oryza rufipogon), a relative of cultivated rice (O.
Lei Tian +6 more
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