Results 31 to 40 of about 1,424,654 (267)
Research progress on the interaction between ferroptosis and inflammatory signaling pathway
Zhongguo linchuang yanjiuFerroptosis is a form of cell death characterized by iron-dependent lipid peroxidation and the accumulation of reactive oxygen species, distinct from apoptosis and other forms of cell death.
LI Yaling, BAI Yihua, FAN Yang, HUANG Lilan
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Exploring the mechanisms of lithium neurotoxicity based on network toxicology and molecular docking
Ecotoxicology and Environmental SafetyThe rapid growth of lithium (Li)-related industrial activities and the application of Li-containing products have become an emerging human health concern.
Wei Wei +4 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Animals, 2021 Chicken is important livestock that serves as a vital food source which remain largely affected by heat stress. Therefore, we performed the transcriptome analysis to help understand the mechanisms of heat stress response in chickens.
Hana Kim +6 more
doaj +1 more source
The insulin signalling pathway [PDF]
Current Biology, 2002 A key aim for future research is to identify the hydrophobic motif kinase that phosphorylates PKB, S6K, SGK and to establish how this protein kinase(s) is regulated by PtdIns(3,4,5)P3. It is also becoming obvious that the information obtained by the overexpression of constitutively active and dominant negative mutants of protein kinases is not ...
Lizcano, Jose M., Alessi, Dario R.
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
Wnt signal transduction pathways [PDF]
Organogenesis, 2008 The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. The Wnts are secreted glycoproteins and comprise a large family of nineteen proteins in humans hinting to a daunting ...
Yuko, Komiya, Raymond, Habas
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Retroactive Signaling in Short Signaling Pathways
PLoS ONE, 2012 في مسارات الإشارات الكيميائية الحيوية دون وصلات تغذية مرتدة صريحة، عادة ما يوصف نقل الإشارة الأساسية بأنه اتصال أحادي الاتجاه، ينتقل من المنبع إلى المصب في سلسلة تغذية أمامية أو شبكة من دورات التعديل التساهمية. في هذه الورقة، نستكشف إمكانية وجود نوع جديد من الإشارات يسمى الإشارات بأثر رجعي، والتي توفرها الخاصية التي تم إظهارها مؤخرًا للأثر الرجعي في ...
Jacques Alexandre Sepulchre +2 more
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Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Signaling Pathways in Pregnancy
Cells, 2022 We are pleased to present this Special Issue of Cells, entitled ‘Signaling Pathways in Pregnancy’ [...]
Giovanni Tossetta, Daniela Marzioni
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