Results 31 to 40 of about 1,569,209 (311)
Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma [PDF]
, 2015 Medulloblastoma is the most common malignant childhood brain tumor and is associated with a poor outcome. There is an urgent need to develop novel targeted therapeutic approaches for medulloblastoma, which will arise from an enhanced understanding of the
Dimitrova, Valeriya, Arcaro, Alexandre
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MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma [PDF]
, 2021 Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic and clinical researchers. The MAPK/ERK signaling pathway
Simon Weonsang Ro, Hyuk Moon
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Wu-Mei-Wan Ameliorates Murine Ulcerative Colitis by Regulating Macrophage Polarization
Frontiers in Pharmacology, 2022 An increasing body of evidence shows that macrophages play an important role in the pathogenesis of ulcerative colitis (UC). Macrophage polarization and changes in related signaling pathways are reported to have a protective effect on intestinal ...
Shuguang Yan +14 more
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Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
Molecular Cancer, 2022 Background The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults.
Hui Zhao +7 more
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Signaling Pathways in Melanogenesis [PDF]
International Journal of Molecular Sciences, 2016 Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones, heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in response to a complex network of interacting regulatory pathways. Melanins are pigment molecules that are endogenously synthesized by melanocytes.
Stacey D’Mello +3 more
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The phosphoinositide 3-kinase signaling pathway as a therapeutic target in grade IV brain tumors [PDF]
, 2011 Brain tumors comprise a wide variety of neoplasia classified according to their cellular origin and their morphological and histological characteristics.
A. Arcaro +5 more
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The role of myofibroblasts in orthodontic tooth movement
口腔疾病防治, 2019 Myofibroblasts are fibroblasts with contractile function. As a contractile cell, myofibroblasts can regulate the function of normal organs in normal tissues.
PAN Xumeng, LIU Yi
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“Biomechanical Signaling in Oocytes and Parthenogenetic Cells”
Frontiers in Cell and Developmental Biology, 2021 Oocyte-specific competence remains one of the major targets of current research in the field of reproduction. Several mechanisms are involved in meiotic maturation and the molecular signature of an oocyte is considered to reflect its quality and to ...
Georgia Pennarossa +2 more
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Signaling on the Endocytic Pathway [PDF]
Traffic, 2001 Ligand binding to receptor tyrosine kinases and G‐protein‐coupled receptors initiates signal transduction events and induces receptor endocytosis via clathrin‐coated pits and vesicles. While receptor‐mediated endocytosis has been traditionally considered an effective mechanism to attenuate ligand‐activated responses, more recent studies demonstrate ...
P S, McPherson, B K, Kay, N K, Hussain
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Endocrine Journal, 1996 GH has long been known as a regulator of body growth and metabolism, yet its mechanism of action at the cellular level has been elusive. We have recently shown that GH promotes the rapid association of GH receptor with the tyrosine kinase JAK2, activates JAK2, and promotes the tyrosyl phosphorylation of both JAK2 and GH receptor. This suggests that the
CARTER-SU, CHRISTIN +5 more
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