Results 51 to 60 of about 1,569,209 (311)
Exploring the mechanisms of lithium neurotoxicity based on network toxicology and molecular docking
Ecotoxicology and Environmental SafetyThe rapid growth of lithium (Li)-related industrial activities and the application of Li-containing products have become an emerging human health concern.
Wei Wei +4 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Signal transduction pathways to apoptosis [PDF]
Trends in Cell Biology, 1994 Recent work has demonstrated that a number of signalling events, including cytosolic Ca(2+) rises, cAMP accumulation, activation of protein kinase C, activation of protein tyrosine kinases, and production of ceramide, regulate apoptosis in diverse model systems.
D J, McConkey, S, Orrenius
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Fish viperin exerts a conserved antiviral function through RLR-triggered IFN signaling pathway [PDF]
, 2014 Mammalian viperin is a typical interferon (IFN)-induced antiviral protein. Fish have viperin homologs; however, little is known about the expression regulation of fish viperins. In this study, we report the expression regulation and antiviral function of
Zhang, Yi-Bing +5 more
core +1 more source
Animals, 2021 Chicken is important livestock that serves as a vital food source which remain largely affected by heat stress. Therefore, we performed the transcriptome analysis to help understand the mechanisms of heat stress response in chickens.
Hana Kim +6 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Encephalomyocarditis virus abrogates the IFN-β signaling pathway via its structural protein VP2 [PDF]
, 2020 Type I interferon (IFN) - mediated antiviral responses are critical at modulating host-virus responses and indeed viruses have evolved strategies to antagonize this pathway.
Xu, Shujuan +8 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source