Results 1 to 10 of about 317,386 (198)

Roles of ERK signaling pathway in regulating myelination of the peripheral nervous system [PDF]

Frontiers in Molecular Neuroscience
Myelination of Schwann cells is a complex biological process that plays a crucial role in peripheral nervous system (PNS) development and repair.
Di Liu, Jingwei Zhou
doaj   +2 more sources

Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials

Genes and Diseases, 2023
Molecular target inhibitors have been regularly approved by Food and Drug Administration (FDA) for tumor treatment, and most of them intervene in tumor cell proliferation and metabolism.
Yanlin Song, Zhenfei Bi, Yu Liu, Furong Qin, Yuquan Wei, Xiawei Wei   +5 more
doaj   +3 more sources

The Complex Role of MAPK/ERK Signaling Pathway in Different Types of Thrombocytopenia [PDF]

Current Issues in Molecular Biology
Thrombocytopenia is a common hematological disorder caused by a variety of factors. It often complicates diseases and treatment options for this condition are quite limited. There are no approved drugs for certain types of thrombocytopenia.
Peipei Xue, Maoshan Chen
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Kinase suppressor of Ras 1 (KSR1) promotes liver carcinogenesis via activation of the RAS/RAF/MEK/ERK signaling pathway [PDF]

JHEP Reports
Background & Aims: Mutations in the RAS and RAF genes are frequently observed in various human cancers, leading to persistent activation of the RAS/RAF/MEK/ERK signaling pathway and driving tumorigenesis.
Hyuk Moon, Hyunjung Park, Sangjik Lee, Soyun Lee, Mihyeon Jun, Jaehun Lee, Jiyeon Baek, Hyerin Park, Jieun Bang, Simon Weonsang Ro   +9 more
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MiR-362-3p inhibits the proliferation, migration and EMT of gastric cancer cells by regulating the DEP-1/ERK signaling pathway [PDF]

Scientific Reports
MicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-362-3p participates in the formation and progression of various cancers. However, the role and clinical value of miR-362-3p in GC remain unclear.
Fei Tu, Zhiyuan Li, Lina Yao, Fengyuan He, Yiqing Jia, Lingzhu Wang, Tiesuo Zhao, Sheng Guo, Yan Jin, Zhijun Yang   +9 more
doaj   +2 more sources

Morphoproteomic profiling of the mammalian target of rapamycin (mTOR) signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing's sarcoma (EWS/FLI1) and Wilms' tumor(WT1). [PDF]

, 2013
BackgroundDesmoplastic small round cell tumor (DSRCT) is a rare sarcoma in adolescents and young adults. The hallmark of this disease is a EWS-WT1 translocation resulting from apposition of the Ewing's sarcoma (EWS) gene with the Wilms' tumor (WT1) gene.
Anderson, Pete M, Brown, Robert E, Buryanek, Jamie, Hayes-Jordan, Andrea, Jiang, Yunyun, Kurzrock, Razelle, Subbiah, Vivek   +6 more
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The role of the ERK signaling pathway in promoting angiogenesis for treating ischemic diseases

Frontiers in Cell and Developmental Biology, 2023
The main treatment strategy for ischemic diseases caused by conditions such as poor blood vessel formation or abnormal blood vessels involves repairing vascular damage and encouraging angiogenesis.
Yue-Yue Song, Dan Liang, De-Kun Liu, Lin Lin, Lei Zhang, Wen-Qing Yang, Wen-Qing Yang   +6 more
doaj   +1 more source

Up-regulation of hepatitis C virus replication and production by inhibition of MEK/ERK signaling. [PDF]

PLoS ONE, 2009
BACKGROUND: Viruses interact with and exploit the host cellular machinery for their multiplication and propagation. The MEK/ERK signaling pathway positively regulates replication of many RNA viruses.
Jean Ndjomou, In-woo Park, Ying Liu, Lindsey D Mayo, Johnny J He   +4 more
doaj   +1 more source

MAPK Signaling Pathway Is Essential for Female Reproductive Regulation in the Cabbage Beetle, Colaphellus bowringi

Cells, 2022
The mitogen-activated protein kinase (MAPK) signaling pathway is a well-conserved intracellular signal transduction pathway, and has important roles in mammalian reproduction.
Zijie Huang, Zhong Tian, Yulian Zhao, Fen Zhu, Wen Liu, Xiaoping Wang   +5 more
doaj   +1 more source

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. [PDF]

PLoS Genetics, 2018
Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to ...
Olivia F Duncan, Lucy Granat, Ramya Ranganathan, Vandana K Singh, David Mazaud, Manolis Fanto, David Chambers, Clive G Ballard, Joseph M Bateman   +8 more
doaj   +1 more source