Results 21 to 30 of about 317,386 (198)

Cefotetan-bound human RKIP involves in Ras/Raf1/MEK/ERK signaling pathway

Acta Biochimica et Biophysica Sinica, 2022
Cefotetan is widely used to treat bacterial infections in the clinic owing to its broad spectrum of antibacterial activity. In the present study, we demonstrate that cefotetan can bind to the conserved ligand-binding pocket of human Raf1 kinase ...
Guo Chenyun, Xu Hao, Zhou Yu, Wu Zhihua, Jiang Bin, Chen Hanyu, Lin Donghai   +6 more
doaj   +1 more source

Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway [PDF]

Biochemical and Biophysical Research Communications, 2018
Secretogranin III (Scg3) was recently discovered as the first highly diabetic retinopathy-associated angiogenic factor, and its neutralizing antibody alleviated the disease with high efficacy in diabetic mice. Investigation of its molecular mechanisms will facilitate the translation of this novel therapy. Scg3 was reported to induce the phosphorylation
Fen Tang, Mario Thiego F. Pacheco, Ping Chen, Dan Liang, Wei Li   +4 more
openaire   +2 more sources

Reversal of il-1β-mediated human embryonic pulmonary fibroblast transdifferentiation by targeting the ERK signaling pathway [PDF]

Archives of Biological Sciences, 2014
The aim of the present study was to determine whether Interleukin (IL)-1β-mediated human embryonic pulmonary fibroblast transdifferentiation could be reversed by targeting of the ERK signaling pathway.
Jin Long-Teng, He Zhang, Li Chang-Chong, Li Lin, Zhang Wei-Xi   +4 more
doaj   +1 more source

TRAF3IP3 promotes glioma progression through the ERK signaling pathway

Frontiers in Oncology, 2022
TRAF3IP3 was reportedly associated with poor prognosis in patients with melanoma; however, its role in glioma is unknown. We aimed to demonstrate the relationship between TRAF3IP3 and glioma and to investigate the potential role of TRAF3IP3 in glioma.
Qi Lin, Zhen Chen, Zhao-Li Shen, Fei Xue, Jia-Jun Qin, Xi-Peng Kang, Zhong-Rong Chen, Zhong -Yuan Xia, Liang Gao, Xian-Zhen Chen   +9 more
openaire   +3 more sources

Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment. [PDF]

PLoS ONE, 2014
Opioids, acting at μ opioid receptors, are commonly used for pain management. Chronic opioid treatment induces cellular adaptations, which trigger long-term side effects, including constipation mediated by enteric neurons.
Celine Duraffourd, Erica Kumala, Laura Anselmi, Nicholas C Brecha, Catia Sternini   +4 more
doaj   +1 more source

Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling [PDF]

, 2014
Neuroinflammation is characterized by activation of microglial cells, followed by production of nitric oxide (NO), which may have different outcomes on neurogenesis, favoring or inhibiting this process.
Alvarez-Buylla, Alvaro, Ana I. Santos, Ana S. Lourenço, António F. Ambrósio, Arvidsson, Bal-Price, Batchelor, Beckman, Beltran, Ben-Hur, Benraiss, Bergsland, Boje, Bruno P. Carreira, Buck, Butovsky, Cacci, Caetana M. Carvalho, Calabrese, Calabrese, Cappella, Carreira, Carreira, Chao, Chehrehasa, Covacu, Curtis, Davalos, Dawson, Dawson, Doetsch, Ekdahl, Ekdahl, Eriksson, Estrada, Gage, Galea, Giulian, Green, Guix, Hanafy, Ignarro, Inês M. Araújo, Iosif, Ischiropoulos, Keefer, Kempermann, Kettenmann, Keynes, Lane, Lowenstein, Madhusoodanan, Maria I. Morte, Matarredona, Ming, Misko, Moncada, Monje, Monje, Monteiro, Moreno-Lopez, Murillo-Carretero, Murillo-Carretero, Murphy, Nathan, Nimmerjahn, Ormerod, Packer, Parent, Pryor, Radi, Reynolds, Rock, Salvemini, Saura, Sierra, Szabo, Taupin, Torroglosa, Uc, Vallieres, Walton, Zhang, Zhang, Zhang   +85 more
core   +5 more sources

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]

, 2015
BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi, Bauer, Jessica, Carroll, Timothy, Eckmann, Lars, Grippo, Paul J, Jung, Barbara, Ozden, Ozkan, Principe, Daniel R, Spehlmann, Martina E, Staudacher, Jonas J   +9 more
core   +2 more sources

HMGB3 promotes the malignant phenotypes and stemness of epithelial ovarian cancer through the MAPK/ERK signaling pathway

Cell Communication and Signaling, 2023
Background Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the leading cause of cancer-related mortality among women. Our previous study revealed that high HMGB3 levels are associated with poor prognosis and lymph node metastasis in ...
Hanlin Ma, Gonghua Qi, Fang Han, Panpan Gai, Jiali Peng, Beihua Kong   +5 more
doaj   +1 more source

Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. [PDF]

, 2019
The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in
Chang, Yuan-I, Hofmann, Inga, Kong, Guangyao, Letson, Christopher, Liu, Yangang, Loh, Mignon, Padron, Eric, Pear, Warren S, Qian, Shuiming, Rajagopalan, Adhithi, Ranheim, Erik A, Stieglitz, Elliot, Wen, Zhi, Yang, David, You, Xiaona, Zhang, Jing, Zhang, Jingfang, Zhang, Xinmin, Zhong, Xuehua, Zhou, Lan, Zhou, Yun   +20 more
core   +1 more source

Dexamethasone inhibits repair of human airway epithelial cells mediated by glucocorticoid-induced leucine zipper (GILZ). [PDF]

PLoS ONE, 2013
BACKGROUND: Glucocorticoids (GCs) are a first-line treatment for asthma for their anti-inflammatory effects, but they also hinder the repair of airway epithelial injury.
Jingyue Liu, Mingxiang Zhang, Chao Niu, Zhengxiu Luo, Jihong Dai, Lijia Wang, Enmei Liu, Zhou Fu   +7 more
doaj   +1 more source