Results 21 to 30 of about 204,002 (257)
Cells, 2022 The mitogen-activated protein kinase (MAPK) signaling pathway is a well-conserved intracellular signal transduction pathway, and has important roles in mammalian reproduction.
Zijie Huang +5 more
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Rewired ERK-JNK Signaling Pathways in Melanoma [PDF]
Cancer Cell, 2007 Constitutive activation of MEK-ERK signaling is often found in melanomas. Here, we identify a mechanism that links ERK with JNK signaling in human melanoma. Constitutively active ERK increases c-Jun transcription and stability, which are mediated by CREB and GSK3, respectively.
Lopez-Bergami, Pablo +10 more
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Key role of ERK pathway signaling in lupus [PDF]
Autoimmunity, 2009 Systemic lupus erythematosus is a poorly understood autoimmune disease, characterized by autoantibodies to nuclear antigens and immune complex deposition in organs like the kidney. Current evidence indicates that a pathologic CD4+T cell subset, characterized by impaired extracellular signal-regulated kinase (ERK) pathway signaling, DNA hypomethylation,
Gabriela, Gorelik, Bruce, Richardson
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Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. [PDF]
PLoS Genetics, 2018 Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to ...
Olivia F Duncan +8 more
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Frontiers in Molecular Biosciences, 2021 Few studies have reported whether nutrients in the tumor microenvironment can regulate the expression of PD-L1. Since tumor cells are often situated in a low-glutamine environment, we investigated PD-L1 expression under glutamine deprivation in bladder ...
Liping Wang +12 more
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Regulation of the ERK signalling pathway in the developing mouse blastocyst [PDF]
Development, 2019 ABSTRACT Activation of the ERK signalling pathway is essential for the differentiation of the inner cell mass (ICM) during mouse preimplantation development. We show here that ERK phosphorylation occurs in ICM precursor cells, in differentiated primitive endoderm (PrE) cells as well as in the mature, formative state epiblast (Epi).
Takuya Azami +6 more
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Scientific Reports, 2021 Despite extensive research on molecular pathways controlling the process of regeneration in model organisms, little is known about the actual initiation signals necessary to induce regeneration. Recently, the activation of ERK signaling has been shown to
V. Jaenen +7 more
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Cefotetan-bound human RKIP involves in Ras/Raf1/MEK/ERK signaling pathway
Acta Biochimica et Biophysica Sinica, 2022 Cefotetan is widely used to treat bacterial infections in the clinic owing to its broad spectrum of antibacterial activity. In the present study, we demonstrate that cefotetan can bind to the conserved ligand-binding pocket of human Raf1 kinase ...
Guo Chenyun +6 more
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Convergence of Signaling Pathways on the Activation of ERK in B Cells [PDF]
Journal of Biological Chemistry, 2002 The B cell receptor (BCR) initiates three major signaling pathways: the Ras pathway, which leads to extracellular signal-regulated kinase (ERK) activation; the phospholipase C-gamma pathway, which causes calcium mobilization; and the phosphoinositide 3-kinase (PI 3-kinase) pathway. These combine to induce different biological responses depending on the
Anand, Jacob +3 more
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Reversal of il-1β-mediated human embryonic pulmonary fibroblast transdifferentiation by targeting the ERK signaling pathway [PDF]
Archives of Biological Sciences, 2014 The aim of the present study was to determine whether Interleukin (IL)-1β-mediated human embryonic pulmonary fibroblast transdifferentiation could be reversed by targeting of the ERK signaling pathway.
Jin Long-Teng +4 more
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