Results 31 to 40 of about 204,002 (257)
Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment. [PDF]
PLoS ONE, 2014 Opioids, acting at μ opioid receptors, are commonly used for pain management. Chronic opioid treatment induces cellular adaptations, which trigger long-term side effects, including constipation mediated by enteric neurons.
Celine Duraffourd +4 more
doaj +1 more source
The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity [PDF]
Cell, 2015 Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role for Ras-Erk-ETS signaling in aging in Drosophila. We show that inhibition of Ras is sufficient for lifespan extension downstream of reduced insulin/IGF-1 (IIS) signaling ...
Cathy Slack +5 more
openaire +5 more sources
Cell Communication and Signaling, 2023 Background Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the leading cause of cancer-related mortality among women. Our previous study revealed that high HMGB3 levels are associated with poor prognosis and lymph node metastasis in ...
Hanlin Ma +5 more
doaj +1 more source
A Reversible Process Calculus and the Modelling of the ERK Signalling Pathway [PDF]
, 2013 We introduce a reversible process calculus with a new feature of execution control that allows us to change the direction and pattern of computation. This feature allows us to model a variety of modes of reverse computation, ranging from strict backtracking to reversing which respects causal ordering of events, and even reversing which violates causal ...
Iain Phillips 0001 +2 more
openaire +1 more source
Targeting the ERK signaling pathway in cancer therapy
Annals of Medicine, 2006 The extracellular signal-regulated kinase (ERK) signaling pathway is a major determinant in the control of diverse cellular processes such as proliferation, survival, differentiation and motility. This pathway is often up-regulated in human tumors and as such represents an attractive target for the development of anticancer drugs.
Kohno, Michiaki, Pouyssegur, Jacques
openaire +3 more sources
Kidney & Blood Pressure Research, 2018 Background/Aims: Nephrolithiasis plagues a great number of patients all over the world. Increasing evidence shows that the extracellular signal-regulated kinase (ERK) signaling pathway and renal tubular epithelial cell (RTEC) dysfunction and attrition ...
Ling Sun +6 more
doaj +1 more source
Dexamethasone inhibits repair of human airway epithelial cells mediated by glucocorticoid-induced leucine zipper (GILZ). [PDF]
PLoS ONE, 2013 BACKGROUND: Glucocorticoids (GCs) are a first-line treatment for asthma for their anti-inflammatory effects, but they also hinder the repair of airway epithelial injury.
Jingyue Liu +7 more
doaj +1 more source
Propagation of human prostate cancer stem-like cells occurs through EGFR-mediated ERK activation. [PDF]
PLoS ONE, 2013 Prostate cancer stem-like cells (PCSCs) are being intensely investigated largely owing to their contributions towards prostate tumorigenesis, however, our understanding of PCSC biology, including their critical pathways, remains incompletely understood ...
Adrian P Rybak +2 more
doaj +1 more source
TRAF3IP3 promotes glioma progression through the ERK signaling pathway
Frontiers in Oncology, 2022 TRAF3IP3 was reportedly associated with poor prognosis in patients with melanoma; however, its role in glioma is unknown. We aimed to demonstrate the relationship between TRAF3IP3 and glioma and to investigate the potential role of TRAF3IP3 in glioma.
Qi Lin +9 more
openaire +3 more sources
DA-Raf-Mediated Suppression of the Ras--ERK Pathway Is Essential for TGF-β1-Induced Epithelial-Mesenchymal Transition in Alveolar Epithelial Type 2 Cells. [PDF]
PLoS ONE, 2015 Myofibroblasts play critical roles in the development of idiopathic pulmonary fibrosis by depositing components of extracellular matrix. One source of lung myofibroblasts is thought to be alveolar epithelial type 2 cells that undergo epithelial ...
Haruko Watanabe-Takano +4 more
doaj +1 more source