Dynamic Akt/mTOR Signaling in Children with Autism Spectrum Disorder. [PDF]
, 2017 Autism spectrum disorder (ASD) is a behaviorally defined disorder affecting 1 in 68 children. Currently, there is no known cause for the majority of ASD cases nor are there physiological diagnostic tools or biomarkers to aid behavioral diagnosis.
Ashwood, Paul +3 more
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Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway
Molecular Systems Biology, 2020 Activating mutations in RAS are present in ~ 30% of human tumors, and the resulting aberrations in ERK/MAPK signaling play a central role in oncogenesis.
Taryn E Gillies +5 more
doaj +1 more source
Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations. [PDF]
PLoS ONE, 2018 Cell signaling is the process by which extracellular information is transmitted into the cell to perform useful biological functions. The ERK (extracellular-signal-regulated kinase) signaling controls several cellular processes such as cell growth ...
Yaman Arkun, Mohammadreza Yasemi
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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
Cell Reports, 2021 Summary: Flux through the RAF-MEK-ERK protein kinase cascade is shaped by phosphatases acting on the core components of the pathway. Despite being an established drug target and a hub for crosstalk regulation, little is known about dephosphorylation of ...
Eunice Cho +4 more
doaj +1 more source
Canonical RTK-Ras-ERK signaling and related alternative pathways [PDF]
WormBook, 2013 Receptor Tyrosine Kinase (RTK)-Ras-Extracellular signal-regulated kinase (ERK) signaling pathways control many aspects of C. elegans development and behavior. Studies in C. elegans helped elucidate the basic framework of the RTK-Ras-ERK pathway and continue to provide insights into its complex regulation, its biological roles, how it elicits cell-type ...
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The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation [PDF]
The EMBO Journal, 2004 Schwann cells are a regenerative cell type. Following nerve injury, a differentiated myelinating Schwann cell can dedifferentiate and regain the potential to proliferate. These cells then redifferentiate during the repair process. This behaviour is important for successful axonal repair, but the signalling pathways mediating the switch between the two ...
Marie C, Harrisingh +5 more
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Generation of pulsatile ERK activity in mouse embryonic stem cells is regulated by Raf activity
Scientific Reports, 2023 The extracellular signal-regulated kinase (ERK) is a serine/threonine kinase that is known to regulate cellular events such as cell proliferation and differentiation.
Yayoi Toyooka +5 more
doaj +1 more source
Selective Desensitization of Growth Factor Signaling by Cell Adhesion to Fibronectin [PDF]
, 2007 Cell adhesion to the extracellular matrix is required to execute growth factor (GF)-mediated cell behaviors, such as proliferation. A major underlying mechanism is that cell adhesion enhances GF-mediated intracellular signals, such as extracellular ...
Asthagiri, Anand R. +3 more
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Evodiamine inhibits adipogenesis via the EGFR–PKCα–ERK signaling pathway [PDF]
FEBS Letters, 2009 The molecular mechanism of the anti‐adipogenic effect of evodiamine (which has several capsaicin‐like pharmacological actions) was investigated. The evodiamine effect was not blocked by the specific TRPV1 antagonist capsazepine in 3T3‐L1 preadipocytes, whereas its effect was greatly curtailed by inhibitors of protein kinase C (PKC) and epidermal growth
Wang, Ting +2 more
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Isoalantolactone suppresses gallbladder cancer progression via inhibiting the ERK signalling pathway
Pharmaceutical Biology, 2022 Gallbladder cancer (GBC) is the most common malignant tumour of the biliary tract. Isoalantolactone (IAL), an active sesquiterpene lactone compound isolated from the roots of Inula helenium L. (Asteraceae), has antitumour effects.This study investigates the effects of IAL on GBC.In vitro, NOZ and GBC-SD cells were treated with IAL (0, 10, 20 and 40 μM)
Xingyu Lv, Yuqi Lin, Xi Zhu, Xiujun Cai
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