Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]
, 2014 Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
core +7 more sources
PLoS Neglected Tropical Diseases, 2020 Aedes mosquitoes can transmit dengue and several other severe vector-borne viral diseases, thereby influencing millions of people worldwide. Insects primarily control and clear the viral infections via their innate immune systems.
Wen-Quan Liu +12 more
doaj +1 more source
Non-genomic actions of estradiol and 4-OH-tamoxifen on murine breast cancer cells [PDF]
, 2015 Estrogens and tamoxifen do not only exert their effects at the genomic level, but also play a role at the cell membrane activating downstream signaling pathways. We recently characterized an estrogen receptor-positive epithelial murine breast cancer cell
Bal, Elisa Dora +3 more
core +2 more sources
Distinct Neurite Outgrowth Signaling Pathways Converge on ERK Activation
Molecular and Cellular Neuroscience, 1999 Several distinct classes of proteins positively regulate axonal growth; some of these are known to activate the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling cascade, at least in nonneuronal cells. We have found that N-cadherin, as well as laminin (LN) and basic fibroblast growth factor (bFGF), can ...
J C, Perron, J L, Bixby
openaire +2 more sources
Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. [PDF]
, 2016 Inhibitors of BRAFV600E kinase are currently under investigations in preclinical and clinical studies involving BRAFV600E glioma. Studies demonstrated clinical response to such individualized therapy in the majority of patients whereas in some patients ...
Berger, Mitchel S +12 more
core +1 more source
Puerarin Suppress Apoptosis of Human Osteoblasts via ERK Signaling Pathway [PDF]
International Journal of Endocrinology, 2013 Puerarin, the main isoflavone glycoside extracted from Radix Puerariae, is an isoflavone traditional Chinese herb. Previous studies have demonstrated that puerarin could regulate osteoblast proliferation and differentiation to promote bone formation. However, the effect of puerarin on the process of human osteoblasts (hOBs) apoptosis is still unclear ...
Ling-juan Liu +6 more
openaire +3 more sources
STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. [PDF]
, 2011 Clonal deletion of autoreactive B cells is crucial for the prevention of autoimmunity, but the signaling mechanisms that regulate this checkpoint remain undefined. Here we characterize a previously unrecognized Ca(2+)-driven pathway for activation of the
Depeille, Philippe +7 more
core
Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice
Frontiers in Pharmacology, 2022 Ras/Raf/MEK/ERK (Ras-ERK) signaling has been demonstrated to play a role in the effects of drugs of abuse such as cocaine and alcohol, but has not been extensively examined in nicotine-related reward behaviors.
Ilaria Morella +7 more
doaj +1 more source
Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity [PDF]
, 2008 In the previous studies, we showed that strong Fgf8 signaling activates the Ras-ERK pathway to induce cerebellum. Here, we show importance of negative regulation of this pathway.
Asuka Suzuki-Hirano +2 more
core +1 more source
Regulation of the ERK signalling pathway in the developing mouse blastocyst [PDF]
Development, 2019 ABSTRACT Activation of the ERK signalling pathway is essential for the differentiation of the inner cell mass (ICM) during mouse preimplantation development. We show here that ERK phosphorylation occurs in ICM precursor cells, in differentiated primitive endoderm (PrE) cells as well as in the mature, formative state epiblast (Epi).
Takuya Azami +6 more
openaire +3 more sources