Results 41 to 50 of about 317,386 (198)

DA-Raf-Mediated Suppression of the Ras--ERK Pathway Is Essential for TGF-β1-Induced Epithelial-Mesenchymal Transition in Alveolar Epithelial Type 2 Cells. [PDF]

PLoS ONE, 2015
Myofibroblasts play critical roles in the development of idiopathic pulmonary fibrosis by depositing components of extracellular matrix. One source of lung myofibroblasts is thought to be alveolar epithelial type 2 cells that undergo epithelial ...
Haruko Watanabe-Takano, Kazunori Takano, Masahiko Hatano, Takeshi Tokuhisa, Takeshi Endo   +4 more
doaj   +1 more source

Xenoestrogen-Induced ERK-1 and ERK-2 Activation via Multiple Membrane-Initiated Signaling Pathways [PDF]

Environmental Health Perspectives, 2004
Xenoestrogens can mimic or antagonize the activity of physiological estrogens, and the suggested mechanism of xenoestrogen action involves binding to estrogen receptors (ERs). However, the failure of various in vitro or in vivo assays to show strong genomic activity of xenoestrogens compared with estradiol (E2) makes it difficult to explain their ...
Bulayeva, Nataliya N., Watson, Cheryl S.
openaire   +2 more sources

Impact of oxygen concentration changes on ANGPTL8 expression of human pulmonary artery endothelial cells [PDF]

Jichu yixue yu linchuang
Objective To explore the impact of change in oxygen concentration on the expression of angiopoietin-like protein 8 (ANGPTL8) by endothelial cells (HPAECs) of human pulmonary artery, and the role and mechanism of ANGPTL8 in pulmonary hypertension (PH ...
ZHANG Zongli, LI Tao, MA Jingwen, ZHANG Jiaxin, LI Xingchao, XI Shibing
doaj   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Towards pathway‐centric cancer therapies via pharmacogenomic profiling analysis of ERK signalling pathway [PDF]

Clinical and Translational Medicine, 2015
AbstractBackgroundGenomic heterogeneity in human cancers complicates gene‐centric personalized medicine. Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations. Therefore, one possible solution to overcome the heterogeneity challenge is a shift from gene‐centric to pathway‐centric therapies.
Wang, Haiyun, Zheng, Xiaoqi, Wang, Jinzeng, Li, Xujuan, Liu, Yin, Zhang, Fan, Fei, Teng   +6 more
openaire   +4 more sources

Morin Induces Heme Oxygenase-1 via ERK-Nrf2 Signaling Pathway [PDF]

Journal of Cancer Prevention, 2013
Oxidative stress damages to cells or tissues, however, cellular defense systems including heme oxygenase-1 (HO-1) protects them against oxidative stress. Flavonoid compounds can activate cellular defense mechanisms against oxidative stress and it can reduce cell damages.
Park, Ji Young, Kang, Kyoung Ah, Kim, Ki Cheon, Cha, Ji Won, Kim, Eun Hee, Hyun, Jin Won   +5 more
openaire   +2 more sources

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

Polygonum orientale L. Alleviates Myocardial Ischemia-Induced Injury via Activation of MAPK/ERK Signaling Pathway

Molecules, 2023
Although Polygonum orientale L. (PO) has a beneficial effect on treatment of myocardial ischemia (MI), its mechanism remains unclear. This study aimed to explore the pharmacological mechanism of PO against MI through MAPK signaling pathways. Firstly, the
Changli Fu, Mingjin Wang, Yuan Lu, Jie Pan, Yueting Li, Yongjun Li, Yonglin Wang, Aimin Wang, Yong Huang, Jia Sun, Chunhua Liu   +10 more
doaj   +1 more source

Scaffold Proteins Regulating Extracellular Regulated Kinase Function In Cardiac Hypertrophy and Disease

Frontiers in Pharmacology, 2016
The mitogen activated protein kinase (MAPK)-extracellular regulated kinase 1/2 (ERK1/2) pathway is a central downstream signaling pathway that is activated in cardiac muscle cells during mechanical and agonist-mediated hypertrophy.
Yan eLiang, Farah eSheikh
doaj   +1 more source

Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth [PDF]

, 2011
Background: Focal adhesion kinase (FAK) functions in cell migration and signaling through activation of the mitogen-activated protein kinase (MAPK) signaling cascade.
Chen, Ruey-Hwa, Chien, Cheng-Ting, Ghose, Aurnab, Grabbe, Caroline, Kao, Hsiu-Hua, Lai, Tzu-Ting, Lee, Yu-Tao, Palmer, Ruth H, Peng, Kuan-Po, Tsai, Pei-I, Van Vactor, David L., Yeh, Shih-Rung   +11 more
core   +1 more source