Results 41 to 50 of about 204,002 (257)
ERK/MAPK signalling pathway and tumorigenesis (Review)
Experimental and Therapeutic Medicine, 2020 Mitogen-activated protein kinase (MAPK) cascades are key signalling pathways that regulate a wide variety of cellular processes, including proliferation, differentiation, apoptosis and stress responses. The MAPK pathway includes three main kinases, MAPK kinase kinase, MAPK kinase and MAPK, which activate and phosphorylate downstream proteins.
Guo, Yan-Jun +5 more
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Zn 2+ influx activates ERK and Akt signaling pathways [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance While zinc (Zn 2+ ) is a vital ion for cell function and human health, little is known about the role it plays in regulating cell signaling. Here, we use fluorescent tools to study the interaction between Zn 2+ and cell ...
Kelsie J. Anson +2 more
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Viruses, 2018 Newcastle disease virus (NDV) can infect a wide range of domestic and wild bird species. The non-structural V protein of NDV plays an important role in antagonizing innate host defenses to facilitate viral replication.
Zhili Chu +8 more
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RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways [PDF]
PROTEOMICS, 2009 AbstractRNF2, a member of polycomb group (PcG) proteins, is involved in chromatin remodeling. However, mechanisms that regulate RNF2 function are unknown. To identify such mechanisms, RNF2 was expressed in HEK‐293 cells and analyzed by 2‐D electrophoresis.
Prema S, Rao +5 more
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Impact of oxygen concentration changes on ANGPTL8 expression of human pulmonary artery endothelial cells [PDF]
Jichu yixue yu linchuangObjective To explore the impact of change in oxygen concentration on the expression of angiopoietin-like protein 8 (ANGPTL8) by endothelial cells (HPAECs) of human pulmonary artery, and the role and mechanism of ANGPTL8 in pulmonary hypertension (PH ...
ZHANG Zongli, LI Tao, MA Jingwen, ZHANG Jiaxin, LI Xingchao, XI Shibing
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Molecules, 2023 Although Polygonum orientale L. (PO) has a beneficial effect on treatment of myocardial ischemia (MI), its mechanism remains unclear. This study aimed to explore the pharmacological mechanism of PO against MI through MAPK signaling pathways. Firstly, the
Changli Fu +10 more
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ERK and p38 pathways regulate amino acid signalling
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008 The ribosomal protein S6 kinase 1 (S6K1) is emerging as a common downstream target of signalling by hormones and nutrients such as insulin and amino acids. Here, we have investigated how amino acids signal through the S6K1 pathway. First, we found that a commercial anti-phospho-Thr389-S6K1 antibody detects an 80-90 kDa protein that is rapidly ...
Casas-Terradellas, Eduard +4 more
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Frontiers in Pharmacology, 2016 The mitogen activated protein kinase (MAPK)-extracellular regulated kinase 1/2 (ERK1/2) pathway is a central downstream signaling pathway that is activated in cardiac muscle cells during mechanical and agonist-mediated hypertrophy.
Yan eLiang, Farah eSheikh
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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
Cell Reports, 2021 Summary: Flux through the RAF-MEK-ERK protein kinase cascade is shaped by phosphatases acting on the core components of the pathway. Despite being an established drug target and a hub for crosstalk regulation, little is known about dephosphorylation of ...
Eunice Cho +4 more
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Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway
Molecular Systems Biology, 2020 Activating mutations in RAS are present in ~ 30% of human tumors, and the resulting aberrations in ERK/MAPK signaling play a central role in oncogenesis.
Taryn E Gillies +5 more
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