Results 11 to 20 of about 317,386 (198)
MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma [PDF]
Cancers, 2021 Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic and clinical researchers. The MAPK/ERK signaling pathway is activated in more than 50% of human HCC cases; however, activating mutations in RAS and RAF ...
Hyuk Moon, Simon Weonsang Ro
openaire +4 more sources
Rewired ERK-JNK Signaling Pathways in Melanoma [PDF]
Cancer Cell, 2007 Constitutive activation of MEK-ERK signaling is often found in melanomas. Here, we identify a mechanism that links ERK with JNK signaling in human melanoma. Constitutively active ERK increases c-Jun transcription and stability, which are mediated by CREB and GSK3, respectively.
Lopez-Bergami, Pablo +10 more
openaire +4 more sources
Targeting the ERK Signaling Pathway in Melanoma
International Journal of Molecular Sciences, 2019 The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its progression have opened a new era in the treatment of this tumor. Vemurafenib was the first specific kinase inhibitor approved for therapy of advanced melanomas harboring BRAF-activating mutations, followed by dabrafenib and encorafenib.
Paola Savoia +3 more
openaire +6 more sources
Zn 2+ influx activates ERK and Akt signaling pathways [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance While zinc (Zn 2+ ) is a vital ion for cell function and human health, little is known about the role it plays in regulating cell signaling. Here, we use fluorescent tools to study the interaction between Zn 2+ and cell signaling pathways that play a role in cell growth
Kelsie J. Anson +2 more
openaire +2 more sources
ERK/MAPK signalling pathway and tumorigenesis.
Experimental and therapeutic medicine, 2020 Mitogen-activated protein kinase (MAPK) cascades are key signalling pathways that regulate a wide variety of cellular processes, including proliferation, differentiation, apoptosis and stress responses. The MAPK pathway includes three main kinases, MAPK kinase kinase, MAPK kinase and MAPK, which activate and phosphorylate downstream proteins.
Guo, Yan-Jun +5 more
openaire +4 more sources
Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway [PDF]
International Journal of Molecular Sciences, 2020 In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling pathway, the Raf/MEK/ERK pathway can mediate not only cell proliferation and survival but also cell cycle arrest and death in different cell types.
Pui-Kei Wu, Andrew Becker, Jong-In Park
openaire +2 more sources
Frontiers in Molecular Biosciences, 2021 Few studies have reported whether nutrients in the tumor microenvironment can regulate the expression of PD-L1. Since tumor cells are often situated in a low-glutamine environment, we investigated PD-L1 expression under glutamine deprivation in bladder ...
Liping Wang +12 more
doaj +1 more source
Key role of ERK pathway signaling in lupus [PDF]
Autoimmunity, 2009 Systemic lupus erythematosus is a poorly understood autoimmune disease, characterized by autoantibodies to nuclear antigens and immune complex deposition in organs like the kidney. Current evidence indicates that a pathologic CD4+T cell subset, characterized by impaired extracellular signal-regulated kinase (ERK) pathway signaling, DNA hypomethylation,
Gabriela, Gorelik, Bruce, Richardson
openaire +2 more sources
Scientific Reports, 2021 Despite extensive research on molecular pathways controlling the process of regeneration in model organisms, little is known about the actual initiation signals necessary to induce regeneration. Recently, the activation of ERK signaling has been shown to
V. Jaenen +7 more
doaj +1 more source
Valproate activates ERK signaling pathway in primary human hepatocytes [PDF]
Biomedical Papers, 2014 Valproic acid (VPA) is a widely-used anticonvulsant and mood-stabilizing agent. VPA is also known to inhibit histone deacetylases (HDACs) affecting the expression of numerous genes.In the present study, we examined the effect of VPA on the extracellular signal-related kinase (ERK, p42/p44) pathway (Ras-Raf-MEK-ERK) belonging to the mitogen-activated ...
Michal, Bitman +3 more
openaire +2 more sources