Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations. [PDF]
PLoS ONE, 2018 Cell signaling is the process by which extracellular information is transmitted into the cell to perform useful biological functions. The ERK (extracellular-signal-regulated kinase) signaling controls several cellular processes such as cell growth ...
Yaman Arkun, Mohammadreza Yasemi
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Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials
Genes and Diseases, 2023 Molecular target inhibitors have been regularly approved by Food and Drug Administration (FDA) for tumor treatment, and most of them intervene in tumor cell proliferation and metabolism.
Yanlin Song +5 more
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Roles of ERK signaling pathway in regulating myelination of the peripheral nervous system [PDF]
Frontiers in Molecular NeuroscienceMyelination of Schwann cells is a complex biological process that plays a crucial role in peripheral nervous system (PNS) development and repair.
Di Liu, Jingwei Zhou
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The Complex Role of MAPK/ERK Signaling Pathway in Different Types of Thrombocytopenia [PDF]
Current Issues in Molecular BiologyThrombocytopenia is a common hematological disorder caused by a variety of factors. It often complicates diseases and treatment options for this condition are quite limited. There are no approved drugs for certain types of thrombocytopenia.
Peipei Xue, Maoshan Chen
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Kinase suppressor of Ras 1 (KSR1) promotes liver carcinogenesis via activation of the RAS/RAF/MEK/ERK signaling pathway [PDF]
JHEP ReportsBackground & Aims: Mutations in the RAS and RAF genes are frequently observed in various human cancers, leading to persistent activation of the RAS/RAF/MEK/ERK signaling pathway and driving tumorigenesis.
Hyuk Moon +9 more
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MiR-362-3p inhibits the proliferation, migration and EMT of gastric cancer cells by regulating the DEP-1/ERK signaling pathway [PDF]
Scientific ReportsMicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-362-3p participates in the formation and progression of various cancers. However, the role and clinical value of miR-362-3p in GC remain unclear.
Fei Tu +9 more
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Variable thresholds for phosphorylation targets of the ERK signaling pathway. [PDF]
Proc Natl Acad Sci U S ACell fates regulated by ERK respond to different thresholds of signaling strength. In mammalian cells, conditions that activate ERK to submaximal levels are sufficient to sustain proliferation, survival, and transformation, while stimuli that activate ERK to very high levels often lead to cell death or cell cycle arrest.
Hayashi K +5 more
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The role of the ERK signaling pathway in promoting angiogenesis for treating ischemic diseases
Frontiers in Cell and Developmental Biology, 2023 The main treatment strategy for ischemic diseases caused by conditions such as poor blood vessel formation or abnormal blood vessels involves repairing vascular damage and encouraging angiogenesis.
Yue-Yue Song +6 more
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Up-regulation of hepatitis C virus replication and production by inhibition of MEK/ERK signaling. [PDF]
PLoS ONE, 2009 BACKGROUND: Viruses interact with and exploit the host cellular machinery for their multiplication and propagation. The MEK/ERK signaling pathway positively regulates replication of many RNA viruses.
Jean Ndjomou +4 more
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Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway [PDF]
International Journal of Molecular Sciences, 2020 In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling pathway, the Raf/MEK/ERK pathway can mediate not only cell proliferation and survival but also cell cycle arrest and death in different cell types.
Pui-Kei Wu, Andrew Becker, Jong-In Park
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