Results 1 to 10 of about 1,825,906 (262)

SLAMF8 and NINJ2 promote neuroinflammation and oxidative stress through TLR4 NF kappa B pathway in Alzheimer’s disease

Scientific Reports
This study aimed to investigate the expression and role of Signaling Lymphocytic Activation Molecule Family Member 8 (SLAMF8) in Alzheimer’s disease (AD), particularly its interaction with NINJ2 in the TLR4/NF-κB signaling pathway.
Shuo Liu, Yuze He, He Chen, Wenwen Zhao, Heman Xu, Tao Bai, Juan Feng   +6 more
doaj   +1 more source

Research Article The effect of acetate Ringer's solution on inflammatory factors and NF-κB signal pathway in the liver of hemorrhagic shock rats

Genetics and Molecular Research, 2018
Z. P. Xu, Q. Song, Z. L. Qiu, L. Li, Z. H. Du, Z. J. Wang   +5 more
openaire   +1 more source

NF-κB in biology and targeted therapy: new insights and translational implications

Signal Transduction and Targeted Therapy
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses.
Qing Guo, Yizi Jin, Xinyu Chen, Xiaomin Ye, Xin Shen, Mingxi Lin, Cheng Zeng, Teng Zhou, Jian Zhang   +8 more
doaj   +1 more source

PCV2 Induced Endothelial Derived IL-8 Affects MoDCs Maturation Mainly via NF-κB Signaling Pathway

Viruses
Porcine circovirus type 2 (PCV2) infection can cause immunosuppressive diseases in pigs. Vascular endothelial cells (VECs), as the target cells for PCV2, play an important role in the immune response and inflammatory regulation.
Mengyu Zhang, Weicheng Xu, Ning Yang, Zhuowei Li, Shuanghai Zhou, Xuewei Liu, Jianfang Wang, Huanrong Li   +7 more
doaj   +1 more source

NF‐κB affected the serum levels of TNF‐α and IL‐1β via activation of the MAPK/NF‐κB signaling pathway in rat model of acute pulmonary microthromboembolism

Pulmonary Circulation
Pulmonary thromboembolism caused by thrombi blocking major pulmonary artery and its branches, is a frequently encountered phenomenon and an important cause of high morbidity and mortality in lung diseases and may develop into persistent pulmonary ...
Yanfen Zhong, Binbin Liang, Xiaofeng Zhang, Jingtao Li, Decai Zeng, Tongtong Huang, Ji Wu   +6 more
doaj   +1 more source

Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-κB signaling pathway

Cellular and Molecular Biology, 2020
The current research aimed to investigate the effect of miR-7 targeting matrix metalloproteinase 14 (MMP-14) on homocysteine (Hcy)-induced rat cerebral artery vascular smooth muscle cells (VSMCs) proliferation, migration and inflammatory factor expression and its possible mechanism.
Hongdan, Ma, Lei, Wang, Wen, Lv, Zheng, Lv   +3 more
openaire   +2 more sources

miR-675 promotes disease progression of non-small cell lung cancer via activating NF-κB signaling pathway

Cellular and Molecular Biology, 2017
Non-small cell lung cancer (NSCLC) is a major type of lung cancer significantly affected human life. Current studies have revealed potential role of miR-675 in the etiology of lung cancer. Therefore, in this study, we aimed to investigate the role of miR-675 in NSCLC cell line.
Y, Feng, C, Yang, D, Hu, X, Wang, X, Liu
openaire   +2 more sources

Lipopolysaccharide pretreatment inhibits oxidative stress-induced endothelial progenitor cell apoptosis via a TLR4-mediated PI3K/Akt/ NF-κB p65 signaling pathway

Cellular and Molecular Biology, 2019
Endothelial progenitor cells (EPCs) improve neovascularization and endothelium regeneration. Transplantation with EPCs is a therapeutic strategy for the treatment of ischemic diseases. However, the transplanted EPCs are susceptible to adverse environments such as hypoxia, inflammation and oxidative stress.
Meihui, Wang, Liang, Xia, Guosheng, Fu
openaire   +2 more sources

AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways

Journal of Liver, 2017
openaire   +1 more source

Calcium-calcineurin signaling pathway in Candida albicans: A potential drug target

Microbiological Research, 2021
Hui Lu, Manjari Shrivastava, Wanqian Li   +2 more
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