Results 1 to 10 of about 140,188 (119)

Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation [PDF]

Cell Communication and Signaling, 2023
Semaphorin7a (SEMA7A), a membrane-anchored member of the semaphorin protein family, could be involved in a diverse range of immune responses via its receptor integrin β1.
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai   +8 more
doaj   +2 more sources

The Effect of Open Reading Frame 3 of Hepatitis E virus on Cellular NF-κB Activity [PDF]

Basrah Journal of Veterinary Research, 2023
NF-B (Nuclear Factor Kappa B) is a crucial transcription factor that is essential for host survival during pathogen infection in animal and human. Therefore, it has been a main goal for numerous pathogens to modify cellular NF-κB activity to create
Rana Abdulnabi, Rasha Othman, Hussein Abdul Sada   +2 more
doaj   +1 more source

Subunit-Specific Role of NF-κB in Cancer

Biomedicines, 2018
The transcription factor NF-κB is a key player in inflammation, cancer development, and progression. NF-κB stimulates cell proliferation, prevents apoptosis, and could promote tumor angiogenesis as well as metastasis.
Barbara Kaltschmidt, Johannes F. W. Greiner, Hussamadin M. Kadhim, Christian Kaltschmidt   +3 more
doaj   +1 more source

Noncanonical NF-κB in Cancer

Biomedicines, 2018
The NF-κB pathway is a critical regulator of immune responses and is often dysregulated in cancer. Two NF-κB pathways have been described to mediate these responses, the canonical and the noncanonical.
Matthew Tegowski, Albert Baldwin
doaj   +1 more source

The NF-κB Activating Pathways in Multiple Myeloma

Biomedicines, 2018
Multiple myeloma(MM), an incurable plasma cell cancer, represents the second most prevalent hematological malignancy. Deregulated activity of the nuclear factor kappaB (NF-κB) family of transcription factors has been implicated in the pathogenesis ...
Payel Roy, Uday Aditya Sarkar, Soumen Basak   +2 more
doaj   +1 more source

Stable Cells with NF-κB-ZsGreen Fused Genes Created by TALEN Editing and Homology Directed Repair for Screening Anti-inflammation Drugs

Journal of Inflammation Research, 2021
Shuyan Zhang, Tao Luo, Jinke Wang State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, People’s Republic of ChinaCorrespondence: Jinke WangState Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096 ...
Zhang S, Luo T, Wang J
doaj  

Sargassum Fusiforme Polysaccharide SFP-F2 Activates the NF-κB Signaling Pathway via CD14/IKK and P38 Axes in RAW264.7 Cells

Marine Drugs, 2018
Sargassum fusifrome is considered a “longevity vegetable” in Asia. Sargassum fusifrome polysaccharides exhibit numerous biological activities, specially, the modulation of immune response via the NF-κB signaling pathway.
Liujun Chen, Peichao Chen, Jian Liu, Chenxi Hu, Shanshan Yang, Dan He, Ping Yu, Mingjiang Wu, Xu Zhang   +8 more
doaj   +1 more source

NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells

Scientia Pharmaceutica, 2018
NO donating iron nitrosyl complex with 2-aminothiophenyl ligand (2-AmPh complex) was studied for its ability to cause cell death and affect nuclear factor kappa B (NF-κB) signaling.
Tatiana Stupina, Anastasia Balakina, Tatiana Kondrat’eva, Galina Kozub, Natalia Sanina, Alexei Terent’ev   +5 more
doaj   +1 more source

Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signaling.

PLoS ONE, 2010
BackgroundI-kappa B kinase 2 (IKK2 or IKK-beta) is one of the most crucial signaling kinases for activation of NF-kappa B, a transcription factor that is important for inflammation, cell survival and differentiation.
Kalsoom Sughra, Andreas Birbach, Rainer de Martin, Johannes A Schmid   +3 more
doaj   +1 more source

Butyrolactone-I from Coral-Derived Fungus Aspergillus terreus Attenuates Neuro-Inflammatory Response via Suppression of NF-κB Pathway in BV-2 Cells

Marine Drugs, 2018
Butyrolactone-I (ZB5-1) from the coral-derived fungus Aspergillus terreus was investigated in this study to estimate its anti-neuroinflammatory effects on lipopolysaccharide (LPS)-induced BV-2 microglia cells.
Yuan Yuan Zhang, Yi Zhang, Yuan-Bei Yao, Xiao-Ling Lei, Zhong-Ji Qian   +4 more
doaj   +1 more source