Mechanisms of NF-κB p65 and strategies for therapeutic manipulation
Journal of Inflammation Research, 2018 Sivagami Giridharan,1 Mythily Srinivasan2,3 1Department of Oral Medicine, Madha Dental College, Kundrathur, Chennai, TN, India; 2Department of Oral Pathology, Medicine and Radiology, Indiana University School of Dentistry, Indiana University Purdue ...
Giridharan S, Srinivasan M
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CUL4A promotes cell invasion in gastric cancer by activating the NF-κB signaling pathway
Biologics: Targets & Therapy, 2017 Yu Gong,* Xiao-Jun Xiang,* Miao Feng, Jun Chen, Zi-Ling Fang, Jian-Ping Xiong, Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this ...
Gong Y +5 more
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Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy
Journal of Inflammation Research, 2015 Kevin J Ruff,1 Paul L Durham,2 Austin O’Reilly,2 F Daniel Long1 1ESM Technologies, LLC, Carthage, MO, USA; 2Center for Biomedical and Life Sciences, Missouri State University, Springfield, MO, USA Purpose: Eggshell membrane (ESM) has been shown to
Ruff KJ +3 more
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NF-kappa B in colorectal cancer
, 2013 Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide, responsible for more than half a million deaths annually. CRC is a multistep process that entails the accumulation of genetic/epigenetic aberrations, which lead to the simultaneous failure of protective mechanisms and the activation of tumorigenic pathways.
Vaiopoulos, Aristeidis G. +2 more
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Nuclear Factor Kappa B Pathway and human cancer therapeutics [PDF]
, 2009 A thesis submitted in partial fufilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyCancer is one of the major causes of morbidity in the world.
Guo, Xiaoxia
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Development of a secreted cell-permeable NF-κB inhibitor to control inflammation [PDF]
, 2010 PhDRheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease, of unknown aetiology. Several disease-modulating approaches have been developed in the past years, however these are expensive, usually accompanied by unwanted side-effects ...
Koutsokeras, Apostolos
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TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma [PDF]
, 2009 Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (cHL), are dependent on constitutive activation of nuclear factor {kappa}B (NF-{kappa}B).
Inga Vater +25 more
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Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]
, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival ...
Biddlestone, John +4 more
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NF-κB Mutations in Germinal Center B-Cell Lymphomas: Relation to NF-κB Function in Normal B Cells [PDF]
, 2022 Most B cell lymphomas arise from the oncogenic transformation of B cells that have undergone the germinal center (GC) reaction of the T cell-dependent immune response, where high-affinity memory B cells and plasma cells are generated.
Klein, U. +5 more
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The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice [PDF]
, 2007 Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target.
Iancu, Cristina M. +9 more
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