Results 11 to 20 of about 270,662 (312)

Noncanonical NF-κB in Cancer

Biomedicines, 2018
The NF-κB pathway is a critical regulator of immune responses and is often dysregulated in cancer. Two NF-κB pathways have been described to mediate these responses, the canonical and the noncanonical.
Matthew Tegowski, Albert Baldwin
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The NF-κB Activating Pathways in Multiple Myeloma

Biomedicines, 2018
Multiple myeloma(MM), an incurable plasma cell cancer, represents the second most prevalent hematological malignancy. Deregulated activity of the nuclear factor kappaB (NF-κB) family of transcription factors has been implicated in the pathogenesis ...
Payel Roy, Uday Aditya Sarkar, Soumen Basak   +2 more
doaj   +1 more source

The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice [PDF]

, 2007
Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target.
Adriana Albini, Aggarwal BB, Aggarwal S, Airola K, Albini A, Albini A, Ammon HP, Andreas Nerlich, Bachmeier BE, Bachmeier BE, Bachmeier BE, Bachmeier BE, Bachmeier BE, Bachmeier BE, Bachmeier BE, Balduyck M, Banerji A, Beatrice Bachmeier, Benbow U, Benbow U, Bharti AC, Biswas DK, Cailleau R, Cailleau R, Chen H, Chen Z, Commandeur JN, Cristina Iancu, Divya CS, Erwin Schleicher, Garg A, Hahm ER, Hong JH, Hozumi A, Huang MT, Hunter KW, Ichiki K, Kawamori T, Kossakowska AE, Kuo ML, Li L, Limtrakul P, Manna SK, Marianne Jochum, Meade-Tollin LC, Mehta K, Menon LG, Menon LG, Michele Cilli, Mukaida N, Nagabhushan M, Nakshatri H, Netzker R, Noel A, Ohashi Y, Park AM, Park CH, Philip S, Raffaella Dell'Eva, Roberta Vené, Shao ZM, Stetler-Stevenson WG, Tetu B, Ulrich Pfeffer, Vincenti MP, Vincenti MP, Vincenti MP, Westermarck J, Wu JT, Yu G, Zhang RD   +70 more
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Stable Cells with NF-κB-ZsGreen Fused Genes Created by TALEN Editing and Homology Directed Repair for Screening Anti-inflammation Drugs

Journal of Inflammation Research, 2021
Shuyan Zhang, Tao Luo, Jinke Wang State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, People’s Republic of ChinaCorrespondence: Jinke WangState Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096 ...
Zhang S, Luo T, Wang J
doaj  

Sargassum Fusiforme Polysaccharide SFP-F2 Activates the NF-κB Signaling Pathway via CD14/IKK and P38 Axes in RAW264.7 Cells

Marine Drugs, 2018
Sargassum fusifrome is considered a “longevity vegetable” in Asia. Sargassum fusifrome polysaccharides exhibit numerous biological activities, specially, the modulation of immune response via the NF-κB signaling pathway.
Liujun Chen, Peichao Chen, Jian Liu, Chenxi Hu, Shanshan Yang, Dan He, Ping Yu, Mingjiang Wu, Xu Zhang   +8 more
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Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NF kappa B Activation and Suppress Growth of A375 Human Melanoma [PDF]

, 2016
Background/Aim: Constitutive activation of nuclear factor kappa-B (NF kappa B) is a hallmark of various cancer types, including melanoma. Chemotherapy may further increase tumour NF kappa B activity, a phenomenon that, in turn, exacerbates drug ...
Buz\ue1s, Krisztina, K\ufasz, Erzs\ue9bet, Kolozsi, Csongor, Marton, Annam\ue1ria, Quintieri, Luigi, Tubak, Vilmos, Vizler, Csaba, Zagotto, Giuseppe   +7 more
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Nuclear factor-kappa B in the liver of patients with chronic hepatitis C: decreased RelA expression is associated with enhanced fibrosis progression [PDF]

, 2001
The mechanisms of liver damage in chronic hepatitis C virus (HCV) infection are poorly understood. The transcription factor, nuclear factor-kappa B (NF-kappa B), regulates the expression of genes involved in apoptosis, inflammation, and antiviral ...
Boya, P. (Patricia), Civeira, M.P. (María Pilar), Jimenez, C. (Carlos), Larrea, E. (Esther), Majano, P.L. (Pedro Lorenzo), Prieto, J. (Jesús), Sola, J. (Josu)   +6 more
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Constitutive NF-kappa B activity in neurons. [PDF]

Molecular and Cellular Biology, 1994
NF-kappa B is inducible transcription factor present in many cell types in a latent cytoplasmic form. So far, only immune cells including mature B cells, thymocytes, and adherent macrophages have been reported to contain constitutively active forms of NF-kappa B in the nucleus.
Kaltschmidt, Christian, Kaltschmidt, Barbara, Neumann, H., Wekerle, H., Baeuerle, P. A.   +4 more
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NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells

Scientia Pharmaceutica, 2018
NO donating iron nitrosyl complex with 2-aminothiophenyl ligand (2-AmPh complex) was studied for its ability to cause cell death and affect nuclear factor kappa B (NF-κB) signaling.
Tatiana Stupina, Anastasia Balakina, Tatiana Kondrat’eva, Galina Kozub, Natalia Sanina, Alexei Terent’ev   +5 more
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Oscillation dynamics underlie functional switching of NF-κB for B-cell activation. [PDF]

, 2016
Transcription factor nuclear factor kappa B (NF-κB) shows cooperative switch-like activation followed by prolonged oscillatory nuclear translocation in response to extracellular stimuli.
Aihara, Kazuyuki, Behar, Marcelo, Hoffmann, Alexander, Inoue, Kentaro, Okada-Hatakeyama, Mariko, Shinohara, Hisaaki, Tanaka, Gouhei, Yumoto, Noriko   +7 more
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