Results 31 to 40 of about 258,608 (128)

Citrulline inhibits LPS‐induced pyroptosis of RAW264.7 macrophages through NF‐κB signaling pathway

Immunity, Inflammation and Disease, 2023
Background The aim of this study was to investigate the effect of citrulline on the pyroptosis of mouse macrophage RAW264.7 and the mechanism. We investigated the effect of citrulline on pyroptosis of RAW264.7 cell induced by lipopolysaccharide (LPS ...
Li Yin, Xiaomin Wei, Yanjun Zhang, Chengshu Lu, Huakun Wang   +4 more
doaj   +1 more source

Novel Phosphorylations of IKKγ/NEMO

mBio, 2012
Central to NF-κB signaling pathways is IKKγ/NEMO, a regulatory subunit of the cytoplasmic IκB kinase (IKK) complex, which undergoes various posttranslational modifications, specifically phosphorylation, to regulate its function.
Sun Hwa Lee, Zsolt Toth, Lai-Yee Wong, Kevin Brulois, Jim Nguyen, June-Yong Lee, Ebrahim Zandi, Jae U. Jung   +7 more
doaj   +1 more source

MicroRNA Roles in the Nuclear Factor Kappa B Signaling Pathway in Cancer

Frontiers in Immunology, 2018
Nuclear factor kappa B (NF-κB) is a pluripotent and crucial dimer transcription factor that orchestrates various physiological and pathological processes, especially cell proliferation, inflammation, and cancer development and progression.
Jin’en Wu, Juntao Ding, Jing Yang, Xiaola Guo, Yadong Zheng, Yadong Zheng   +5 more
doaj   +1 more source

Novel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKβ and consequential activation of NF-κB signaling pathway

Cell Death and Disease, 2021
NF-κB signaling pathway is a critical link between inflammation and cancer. Emerging evidence suggested that long non-coding RNAs (lncRNAs) were involved in dysregulation of NF-κB.
Yuanxin Xing, Yani Lin, Ying Zhang, Jing Hu, Junmei Liu, Yuanyuan Tian, Jian Zhao, Weiwen Chen, Bo Han   +8 more
doaj   +1 more source

Ambient Particulate Matter Induces Vascular Smooth Muscle Cell Phenotypic Changes via NOX1/ROS/NF-κB Dependent and Independent Pathways: Protective Effects of Polyphenols

Antioxidants, 2021
Epidemiological studies have demonstrated an association between ambient particulate matter (PM) exposure and vascular diseases. Here, we observed that treatment with ambient PM increased cell migration ability in vascular smooth muscle cells (VSMCs) and
Chia-Chi Ho, Yu-Cheng Chen, Ming-Hsien Tsai, Hui-Ti Tsai, Chen-Yi Weng, Shaw-Fang Yet, Pinpin Lin   +6 more
doaj   +1 more source

An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

Frontiers in Pharmacology
Nuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. NF-κB signaling pathway regulates a wide range of physiological processes, such as cell survival, growth, and
Pratibha Pandey, Sorabh Lakhanpal, Danish Mahmood, Han Na Kang, Byunggyu Kim, Sojin Kang, Jinwon Choi, Min Choi, Shivam Pandey, Mahakshit Bhat, Shilpa Sharma, Fahad Khan, Moon Nyeo Park, Bonglee Kim, Bonglee Kim   +14 more
doaj   +1 more source

Hypoxia-induced NLRP3 inflammasome activation via the HIF-1α/NF-κB signaling pathway in human dental pulp fibroblasts

BMC Oral Health
Background Previous studies have reported the link between hypoxic conditions and NLRP3 inflammasome-mediated pulpal inflammation in the progression of pulpitis. However, the underlying mechanism has not been fully elucidated.
Diya Wang, Minghao Wang, Shukai Sun, Chongyang Zhang, Ya Song, Jianing Li, Bing Song, Haipeng Lv, Shengchao Wang, Wenkai Jiang   +9 more
doaj   +1 more source

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1

Viruses, 2013
The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3
Benjamin E. Gewurz, Ina Ersing, Katharina Bernhardt   +2 more
doaj   +1 more source

A parapoxviral virion protein inhibits NF-κB signaling early in infection.

PLoS Pathogens, 2017
Poxviruses have evolved unique proteins and mechanisms to counteract the nuclear factor κB (NF-κB) signaling pathway, which is an essential regulatory pathway of host innate immune responses.
Sushil Khatiwada, Gustavo Delhon, Ponnuraj Nagendraprabhu, Sabal Chaulagain, Shuhong Luo, Diego G Diel, Eduardo F Flores, Daniel L Rock   +7 more
doaj   +1 more source

Role of IKK/NF-κB signaling in extinction of conditioned place aversion memory in rats. [PDF]

PLoS ONE, 2012
The inhibitor κB protein kinase/nuclear factor κB (IKK/NF-κB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-κB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown.
Cheng-Hao Yang, Xiang-Ming Liu, Ji-Jian Si, Hai-Shui Shi, Yan-Xue Xue, Jian-Feng Liu, Yi-Xiao Luo, Chen Chen, Peng Li, Jian-Li Yang, Ping Wu, Lin Lu   +11 more
doaj   +1 more source