Results 51 to 60 of about 1,825,906 (262)

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]

, 2011
NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela, Bernd Baumann, Lisa Wiesmüller, Volcic, Meta, Fulda, Simone, Meta Volcic, Volcic, M., Wiesmueller, L., Baumann, B., Daniel, P., Sabine Karl, Simone Fulda, Daniela Salles, Peter Daniel, Karl, Sabine, Baumann, Bernd, Fulda, S., Salles, D., Karl, S., Daniel, Peter, Wiesmüller, Lisa   +20 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ambient Particulate Matter Induces Vascular Smooth Muscle Cell Phenotypic Changes via NOX1/ROS/NF-κB Dependent and Independent Pathways: Protective Effects of Polyphenols

Antioxidants, 2021
Epidemiological studies have demonstrated an association between ambient particulate matter (PM) exposure and vascular diseases. Here, we observed that treatment with ambient PM increased cell migration ability in vascular smooth muscle cells (VSMCs) and
Chia-Chi Ho, Yu-Cheng Chen, Ming-Hsien Tsai, Hui-Ti Tsai, Chen-Yi Weng, Shaw-Fang Yet, Pinpin Lin   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Novel Phosphorylations of IKKγ/NEMO

mBio, 2012
Central to NF-κB signaling pathways is IKKγ/NEMO, a regulatory subunit of the cytoplasmic IκB kinase (IKK) complex, which undergoes various posttranslational modifications, specifically phosphorylation, to regulate its function.
Sun Hwa Lee, Zsolt Toth, Lai-Yee Wong, Kevin Brulois, Jim Nguyen, June-Yong Lee, Ebrahim Zandi, Jae U. Jung   +7 more
doaj   +1 more source

Novel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKβ and consequential activation of NF-κB signaling pathway

Cell Death and Disease, 2021
NF-κB signaling pathway is a critical link between inflammation and cancer. Emerging evidence suggested that long non-coding RNAs (lncRNAs) were involved in dysregulation of NF-κB.
Yuanxin Xing, Yani Lin, Ying Zhang, Jing Hu, Junmei Liu, Yuanyuan Tian, Jian Zhao, Weiwen Chen, Bo Han   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

MicroRNA Roles in the Nuclear Factor Kappa B Signaling Pathway in Cancer

Frontiers in Immunology, 2018
Nuclear factor kappa B (NF-κB) is a pluripotent and crucial dimer transcription factor that orchestrates various physiological and pathological processes, especially cell proliferation, inflammation, and cancer development and progression.
Jin’en Wu, Juntao Ding, Jing Yang, Xiaola Guo, Yadong Zheng, Yadong Zheng   +5 more
doaj   +1 more source

Resveratrol inhibits enterovirus 71 replication and pro-inflammatory cytokine secretion in rhabdosarcoma cells through blocking IKKs/NF-κB signaling pathway. [PDF]

, 2015
Polydatin and resveratrol, as major active components in Polygonum cuspidatum, have anti-inflammatory, antioxidant and antitumor functions. However, the effect and mechanism of polydatin and resveratrol on enterovirus 71 (EV71) have not been reported. In
Wang, Yuyue, Zhiwen Gu, Jingtin Jiang, Li, Yuanyuan, Weifeng Shi, Zhang, Li, Ji, Yun, Yuyue Wang, Li Zhang, Xiaopeng Xu, Xu, Xiaopeng, Jiang, Jingtin, Yuanyuan Li, Yun Ji, Zhang, Lirong, Jing Sun, Lirong Zhang, Shi, Weifeng, Mei Shi, Gu, Zhiwen, Sun, Jing, Shi, Mei   +21 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source