Results 41 to 50 of about 1,825,906 (262)

TRIM14 Promotes Noncanonical NF‐κB Activation by Modulating p100/p52 Stability via Selective Autophagy

Advanced Science, 2020
The noncanonical NF‐κB signaling pathway plays a critical role in a variety of biological functions including chronic inflammation and tumorigenesis. Activation of noncanonical NF‐κB signaling largely relies on the abundance as well as the processing of ...
Meixin Chen, Zhiyao Zhao, Qingcai Meng, Puping Liang, Zexiong Su, Yaoxing Wu, Junjiu Huang, Jun Cui   +7 more
doaj   +1 more source

Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy

Frontiers in Oncology, 2022
BackgroundTumors often progress to a more aggressive phenotype to resist drugs. Multiple dysregulated pathways are behind this tumor behavior which is known as cancer chemoresistance. Thus, there is an emerging need to discover pivotal signaling pathways
Sajad Fakhri, Seyed Zachariah Moradi, Seyed Zachariah Moradi, Akram Yarmohammadi, Fatemeh Narimani, Carly E. Wallace, Anupam Bishayee   +6 more
doaj   +1 more source

An unexpected twist to the activation of IKKβ:TAK1 primes IKKβ for activation by autophosphorylation [PDF]

, 2014
IKKß {IkB [inhibitor of NF-?B (nuclear factor ?B)] kinase ß} is required to activate the transcription factor NF-?B, but how IKKß itself is activated in vivo is still unclear.
Lawrence, T., Peggie, M. W., Lawrence, Toby, Peggie, Mark W., Clark, Kristopher, Cohen, P., Cohen, Philip; id_orcid, Clark, K., Zhang, Jiazhen, Zhang, J.   +9 more
core   +1 more source

lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer

Molecular Cancer, 2020
Background The activation of NF-κB signaling pathway is regarded as the dominant process that correlates with tumorigenesis. Recently, increasing evidence shows that long noncoding RNAs (lncRNAs) play crucial roles in sustaining the NF-κB signaling ...
Xiaofan Ren, Changhao Chen, Yuming Luo, Mingyang Liu, Yuting Li, Shangyou Zheng, Huilin Ye, Zhiqiang Fu, Min Li, Zhihua Li, Rufu Chen   +10 more
doaj   +1 more source

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, Bernd L., Aderogba, Mutalib A., Okorji, Uchechukwu P., Okorji, U. P., Fiebich, B.L., Olajide, Olumayokun A.   +6 more
core   +1 more source

Functions of Drosophila Toll/NF-κB signaling in imaginal tissue homeostasis and cancer

Frontiers in Cell and Developmental Biology
The Toll/NF-κB pathway plays a central role in patterning the Drosophila embryo and in orchestrating the innate immune response against microbial infections. Both discoveries were associated with a Nobel Prize award and led to the recognition of the Toll-
Fabienne Brutscher, Konrad Basler
doaj   +1 more source

NF-κB—An Important Player in Xenoestrogen Signaling in Immune Cells

Cells, 2021
The proper functioning of the immune system is critical for an effective defense against pathogenic factors such as bacteria and viruses. All the cellular processes taking place in an organism are strictly regulated by an intracellular network of ...
Karolina Nowak, Ewa Jabłońska, Wioletta Ratajczak-Wrona   +2 more
doaj   +1 more source

Tiliroside Produced Anti-Neuroinflammatory Effects Through Interference With NF-κB And MAPK Signalling In LPS+ IFN-γ Stimulated BV-2 Microglia. [PDF]

, 2014
Tiliroside is a glycosidic flavonoid, which possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities. It is contained in several dietary plants like linden, rosehip, raspberry and strawberry [1, 2].
Aderogba, Mutallib A., Olajide, Olumayokun A, Velagapudi, Ravikanth   +2 more
core   +1 more source

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +1 more source

Citrulline inhibits LPS‐induced pyroptosis of RAW264.7 macrophages through NF‐κB signaling pathway

Immunity, Inflammation and Disease, 2023
Background The aim of this study was to investigate the effect of citrulline on the pyroptosis of mouse macrophage RAW264.7 and the mechanism. We investigated the effect of citrulline on pyroptosis of RAW264.7 cell induced by lipopolysaccharide (LPS ...
Li Yin, Xiaomin Wei, Yanjun Zhang, Chengshu Lu, Huakun Wang   +4 more
doaj   +1 more source