Results 41 to 50 of about 258,608 (128)

Huangqi decoction improved the inflammatory response of rats with diabetic nephropathy by inhibiting TLR4/NF-κB signal pathway

Linchuang shenzangbing zazhi, 2022
ObjectiveTo establish an animal model of lipopolysaccharide （LPS）-induced inflammation and observe whether Huangqi Decoction （HD） can improve the inflammatory response in rats with diabetic nephropathy （DN） by inhibiting the TLR4/NF-κB signaling pathway ...
Chi Yang-feng, Liu Shuang, Huang Jie-bo, Li Zhi-jun, Wang Hao, Wang Li, Liang Yong-ping, Wang Yun-man   +7 more
doaj  

Bioactive Compounds and Probiotics Mitigate Mastitis by Targeting NF-κB Signaling Pathway

Biomolecules
Mastitis is a significant inflammatory condition of the mammary gland in dairy cows. It is caused by bacterial infections and leads to substantial economic losses worldwide.
Muhammad Zahoor Khan, Liangliang Li, Tongtong Wang, Xiaotong Liu, Wenting Chen, Qingshan Ma, Muhammad Zahoor, Changfa Wang   +7 more
doaj   +1 more source

IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB Signaling by Targeting TRIF for Degradation in Teleost Fish

Frontiers in Immunology, 2018
NF-κB signaling is tightly regulated and essential to innate and adaptive immune responses, its regulatory mechanism remains unclear in various organisms, especially teleosts.
Xueyan Zhao, Xueyan Zhao, Ruixuan Huo, Xiaolong Yan, Tianjun Xu, Tianjun Xu, Tianjun Xu, Tianjun Xu   +7 more
doaj   +1 more source

Aged garlic attenuates neuroinflammation via modulating the NF-κB pathway: Insights from multi-omics analyses

Food & Nutrition Research
Background: Neuroinflammation is a key pathological feature in many neurodegenerative diseases, and the nuclear factor kappa-B (NF-κB) signaling pathway is a central mediator of this response.
Junjun Meng, Chengquan Wen, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Wenxiu Han, Pei Jiang   +7 more
doaj   +1 more source

Novel components in the nuclear factor-kappa B (NF-κB) signaling pathways of endothelial cells under hyperglycemic-ischemic conditions

Frontiers in Cardiovascular Medicine
Diabetes worsens the outcomes of a number of vascular disorders including peripheral arterial disease (PAD) at least in part through induction of chronic inflammation.
Madhu V. Singh, Thomas Wong, Sonia Moorjani, Arul M. Mani, Ayotunde O. Dokun   +4 more
doaj   +1 more source

Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression.

PLoS ONE, 2017
Cellular FLICE inhibitory protein (c-FLIP) is a key anti-apoptotic regulator that associates with the signaling complex downstream of NF-κB, negatively interfering with apoptotic signaling.
In-Hu Hwang, Seung Yoon Oh, Hyun-Jin Jang, Eunbi Jo, Jong Cheon Joo, Kyung-Bok Lee, Hwa-Seung Yoo, Mi Young Lee, Soo Jung Park, Ik-Soon Jang   +9 more
doaj   +1 more source

Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation

eLife, 2016
Nuclear factor kappa B (NF-κB)-mediated transcription is an important mediator for cellular responses to DNA damage. Genotoxic agents trigger a 'nuclear-to-cytoplasmic' NF-κB activation signaling pathway; however, the early nuclear signaling cascade ...
Kai Fu, Xin Sun, Eric M Wier, Andrea Hodgson, Yue Liu, Cynthia L Sears, Fengyi Wan   +6 more
doaj   +1 more source

CHIP/STUB1 suppresses the transcription and latent reactivation of HIV-1 via the TRAF6-NF-κB-HIV-LTR axis.

PLoS Pathogens
HIV-1 replication, transcription and latency are correlated with the activation of NF-κB signaling. C-terminus of Hsc70-interacting protein (CHIP or STUB1), a cellular E3 ligase, has been reported to inhibit Tat-mediated HIV-1 LTR promoter activity by ...
Wei-Hua Zheng, Sen-Ying Lin, Ze-Lan He, Run-Ze Ni, Dan Mu   +4 more
doaj   +1 more source

p100 Deficiency is insufficient for full activation of the alternative NF-κB pathway: TNF cooperates with p52-RelB in target gene transcription.

PLoS ONE, 2012
BackgroundConstitutive activation of the alternative NF-κB pathway leads to marginal zone B cell expansion and disorganized spleen microarchitecture. Furthermore, uncontrolled alternative NF-κB signaling may result in the development and progression of ...
Agnes Lovas, Anja Weidemann, Daniela Albrecht, Lars Wiechert, Debra Weih, Falk Weih   +5 more
doaj   +1 more source

Progesterone Administration Modulates Cortical TLR4/NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats

Mediators of Inflammation, 2011
Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (
Zhong Wang, Gang Zuo, Xiao-Yong Shi, Jian Zhang, Qi Fang, Gang Chen   +5 more
doaj   +1 more source