Results 61 to 70 of about 1,825,906 (262)

The Neutrophil Gelatinase-associated lipocalin (NGAL), a NF-kB regulated gene, is a survival factor for thyroid neoplastic cells [PDF]

, 2008
NF-κB is constitutively activated in primary human thyroid tumors, particularly in those of anaplastic type. The inhibition of NF-κB activity in the human anaplastic thyroid carcinoma cell line, FRO, leads to an increased susceptibility to ...
Iannetti, Alessio
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Role of IKK/NF-κB signaling in extinction of conditioned place aversion memory in rats. [PDF]

PLoS ONE, 2012
The inhibitor κB protein kinase/nuclear factor κB (IKK/NF-κB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-κB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown.
Cheng-Hao Yang, Xiang-Ming Liu, Ji-Jian Si, Hai-Shui Shi, Yan-Xue Xue, Jian-Feng Liu, Yi-Xiao Luo, Chen Chen, Peng Li, Jian-Li Yang, Ping Wu, Lin Lu   +11 more
doaj   +1 more source

Targeting NF-κB signaling pathway in cancer by dietary polyphenols [PDF]

, 2019
Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the
Silva A. S., Wang F., Filosa, Rosanna, Khan, Haroon, Cao, Hui, Nabavi, Seyed Mohammad, Zou X., Daglia, Maria, Filosa R., Xiao, Jianbo, Castilho P. C. M. F., Zou, Xiaobo, Gomila A. S., D'Onofrio, Grazia, Nabavi S. M., Daglia M., Khan H., Castilho, Paula Cristina Machado Ferreira, Cao H., Wang, Fang, Rengasamy K. R. R., Ou J., D'Onofrio G., Silva, Ana Sanches, Rengasamy, Kannan R. R., Ou, Juanying, Ullah H., Ullah, Hammad, Xiao J., Gomila, Antoni Sureda   +29 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

GEF-H1-RhoA signaling pathway mediates LPS-induced NF-κB transactivation and IL-8 synthesis in endothelial cells [PDF]

, 2012
Secretion of proinflammatory cytokines by LPS activated endothelial cells contributes substantially to the pathogenesis of sepsis. However, the mechanism involved in this process is not well understood. In the present study, we determined the roles of GEF-
Derek Van Lonkhuyzen, Huan, Jingning, Jingning Huan, Van Lonkhuyzen, Derek R., Chengjin Gao, Yi Dou, Feng Guo, Zhou, Zengding, Gao, Chengjin, Dou, Yi, Tang, Jiajun, Jiajun Tang, Guo, Feng, Zengding Zhou   +13 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. [PDF]

, 2010
INTRODUCTION: Streptococcus pneumoniae remains a major global health problem and a leading cause of death in children worldwide. The factors that influence development of pneumococcal sepsis remain poorly understood, although increasing evidence points ...
Rautanen, Anna, Moore, CE, Davies, RJ, J Scott, Adrian VS Hill, Shelley Segal, Berkley, James, Hill, Adrian, Chiea C Khor, Andrew Walley, Catrin E Moore, Hill, AVS, Peshu, N, Davies, Robert JO, Scott, John, Williams, TN, Chapman, Stephen J, James A Berkley, Segal, S, Rautanen, A, Hill, AV, Scott, J Anthony, Fredrik O Vannberg, Walley, A, Khor, Chiea C, Vannberg, Fredrik O, Davies, RJO, Khor, CC, Derrick W Crook, Crook, DW, Moore, Catrin E, Berkley, James A, Segal, Shelley, Berkley, JA, Norbert Peshu, Hill, Adrian VS, Crook, Derrick W, Thomas N Williams, Day, Nicholas P, Day, NP, Vannberg, FO, Peshu, Norbert, Chapman, SJ, Scott, JA, Stephen J Chapman, Nicholas P Day, Anna Rautanen, Williams, Thomas N, Day, Nicholas, Walley, Andrew, Williams, Thomas, Robert JO Davies   +51 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Expanding the Interactome of the Noncanonical NF-κB Signaling Pathway

, 2019
NF-κB signaling is a central pathway of immunity and integrates signal transduction upon a wide array of inflammatory stimuli. Noncanonical NF-κB signaling is activated by a small subset of TNF family receptors and characterized by NF-κB2/p52 ...
Wojciech Garncarz (2899964), Ana Krolo (2899958), Kaan Boztug (2164924), Roberto Sacco (1307208), Sylvia Knapp (54718), Keiryn L. Bennett (2899955), Katharina L. Willmann (2899961), Rui Martins (577546)   +7 more
core   +2 more sources